Reactome | Regulation of ornithine decarboxylase (ODC)

Regulation of ornithine decarboxylase (ODC)

Stable Identifier

R-HSA-350562

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Regulation of ornithine decarboxylase (ODC)

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Polyamines increase the production of antizyme (AZ). The carboxy-terminal half of antizyme interacts with ODC, generating an inactive AZ:ODC heterodimer complex. A carboxy-terminal domain of ODC is exposed only within the heterodimer, and is the target for subsequent degradation. A domain within the amino-terminal portion of antizyme provides a function needed for efficient degradation of ODC by the proteasome.
The proteasome cycle starts with the processing of AZ:ODC, sequestering ODC and then degrading it to peptides but releasing AZ. AZ participates in additional rounds of binding and degradation. Antizyme-mediated inhibition and destruction of ODC reduces synthesis of polyamines. Additionally, antizyme also inhibits polyamine transport into the cell. Antizyme production is reduced, completing the regulatory circuit (Coffino, 2001).
The following illustration is adapted from a minireview by Pegg, 2006; J. Biol. Chem., Vol. 281, Issue 21, 14529-14532.

Literature References

PubMed ID	Title	Journal	Year
16205122	Mechanisms of protein degradation: an odyssey with ODC Shaul, Y, Kahana, C, Asher, G	Cell Cycle	2005
10623564	Degradation of ornithine decarboxylase by the 26S proteasome Murakami, Y, Tanaka, K, Hayashi, S, Matsufuji, S, Tanahashi, N	Biochem Biophys Res Commun	2000
16459331	Regulation of ornithine decarboxylase Pegg, AE	J Biol Chem	2006