Antizyme OAZ binds to Ornithine decarboxylase

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Antizyme is a non-competitive inhibitor of ODC that is synthesized in response to an increase in polyamine concentration. Tight binding of the antizyme to the ODC monomer forming a heterodimer prevents enzymatic activity. The region of antizyme interacting with ODC is contained in a section involving residues 106–212 in the COOH-terminal half of the antizyme molecule. The induction of antizyme thus leads to a loss of active ODC protein (Pegg, 2006 and references cited in that review).

Literature References
PubMed ID Title Journal Year
9132164 Molcecular cloning of human antizyme cDNA

Itoh, S, Hayashi, H, Yang, D, Hayashi, M, Onozaki, K, Takii, T

Biochem Mol Biol Int 1996
12359729 Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase

MacDonald, A, Coffino, P, Chen, H

J Biol Chem 2002
12660156 Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate

Coffino, P, Zhang, M, Pickart, CM

EMBO J 2003
7811704 Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme

Tewari, M, Pieringer, J, Taub, R, Thornton, RD, Mochan, E, Qian, Y, Tewari, DS

Biochim Biophys Acta 1994
Orthologous Events
Cite Us!