Reactome | Antizyme OAZ binds to Ornithine decarboxylase

Antizyme OAZ binds to Ornithine decarboxylase

Stable Identifier

R-HSA-350567

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Antizyme OAZ binds to Ornithine decarboxylase

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Members of the OAZ (Ornithine decarboxylase antizyme) protein family bind ODC (ornithine decarboxylase) monomers (Kanerva et al. 2008), preventing the latter from dimerizing to form catalytically active ODC (Pegg 2006; Zhang et al. 2003). AZIN1 (Antizyme inhibitor 1) negatively regulates OAZ - ODC interaction by itself binding OAZ (Wu et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
12359729	Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase Chen, H, MacDonald, A, Coffino, P	J Biol Chem	2002
17900240	Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase Kanerva, K, Mäkitie, LT, Pelander, A, Heiskala, M, Andersson, LC	Biochem J	2008
12660156	Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate Zhang, M, Pickart, CM, Coffino, P	EMBO J	2003
26443277	Structural basis of Ornithine Decarboxylase inactivation and accelerated degradation by polyamine sensor Antizyme1 Wu, D, Kaan, HY, Zheng, X, Tang, X, He, Y, Vanessa Tan, Q, Zhang, N, Song, H	Sci Rep	2015
16459331	Regulation of ornithine decarboxylase Pegg, AE	J Biol Chem	2006
7811704	Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme Tewari, DS, Qian, Y, Thornton, RD, Pieringer, J, Taub, R, Mochan, E, Tewari, M	Biochim Biophys Acta	1994