Reactome | Antizyme OAZ binds to Ornithine decarboxylase

Antizyme OAZ binds to Ornithine decarboxylase

Stable Identifier

R-HSA-350567

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Antizyme OAZ binds to Ornithine decarboxylase

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Antizyme is a non-competitive inhibitor of ODC that is synthesized in response to an increase in polyamine concentration. Tight binding of the antizyme to the ODC monomer forming a heterodimer prevents enzymatic activity. The region of antizyme interacting with ODC is contained in a section involving residues 106–212 in the COOH-terminal half of the antizyme molecule. The induction of antizyme thus leads to a loss of active ODC protein (Pegg, 2006 and references cited in that review).

Literature References

PubMed ID	Title	Journal	Year
9132164	Molcecular cloning of human antizyme cDNA Itoh, S, Hayashi, H, Yang, D, Hayashi, M, Onozaki, K, Takii, T	Biochem Mol Biol Int	1996
12359729	Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase MacDonald, A, Coffino, P, Chen, H	J Biol Chem	2002
12660156	Determinants of proteasome recognition of ornithine decarboxylase, a ubiquitin-independent substrate Coffino, P, Zhang, M, Pickart, CM	EMBO J	2003
7811704	Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme Tewari, M, Pieringer, J, Taub, R, Thornton, RD, Mochan, E, Qian, Y, Tewari, DS	Biochim Biophys Acta	1994