Antizyme is a non-competitive inhibitor of ODC that is synthesized in response to an increase in polyamine concentration. Tight binding of the antizyme to the ODC monomer forming a heterodimer prevents enzymatic activity. The region of antizyme interacting with ODC is contained in a section involving residues 106–212 in the COOH-terminal half of the antizyme molecule. The induction of antizyme thus leads to a loss of active ODC protein (Pegg, 2006 and references cited in that review).
Itoh, S, Hayashi, H, Yang, D, Hayashi, M, Onozaki, K, Takii, T
MacDonald, A, Coffino, P, Chen, H
Coffino, P, Zhang, M, Pickart, CM
Tewari, M, Pieringer, J, Taub, R, Thornton, RD, Mochan, E, Qian, Y, Tewari, DS
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