Reactome | LGMN [lysosomal lumen]

LGMN [lysosomal lumen]

Stable Identifier

R-HSA-350135

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal lumen

Synonyms

Legumain, LGMN_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99538 LGMN

Gene Names

LGMN, PRSC1

Chain

signal peptide:1-17, chain:18-323, propeptide:324-433

Reference Genes

BioGPS Gene:5641 LGMN

COSMIC (genes):LGMN LGMN

CTD Gene:5641 LGMN

dbSNP Gene:5641 LGMN

ENSEMBL:ENSG00000100600 LGMN

HGNC:9472 LGMN

KEGG:hsa:5641 LGMN

Monarch:5641 LGMN

NCBI Gene:5641 LGMN

OMIM:602620 LGMN

UCSC:Q99538 LGMN

Reference Transcript

Other Identifiers

11733728_a_at

11733729_s_at

11746287_x_at

11748110_a_at

11752744_a_at

11752745_x_at

16796060

201212_PM_at

201212_at

317_at

3516537

3516538

3516542

3577079

3577080

3577081

3577083

3577084

3577085

3577088

3577089

3577091

3577092

3577094

3577095

3577096

3577097

3577098

3577099

3577100

3577101

3577103

3577104

3577105

3577106

3577107

3577108

3577114

3577115

3577116

3577121

51728_at

5641

7980958

A_23_P25994

D55696_at

GE57264

GO:0002376

GO:0003014

GO:0003824

GO:0004175

GO:0004197

GO:0005576

GO:0005737

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0006508

GO:0006624

GO:0006629

GO:0006766

GO:0007613

GO:0008092

GO:0008233

GO:0008234

GO:0008284

GO:0008306

GO:0010447

GO:0010629

GO:0016787

GO:0019886

GO:0031410

GO:0032801

GO:0035729

GO:0036021

GO:0040015

GO:0042359

GO:0043202

GO:0043226

GO:0043524

GO:0045177

GO:0045931

GO:0048156

GO:0048471

GO:0050877

GO:0051603

GO:0051604

GO:0061133

GO:0070062

GO:0071277

GO:0090026

GO:0097061

GO:0097202

GO:0097264

GO:0098772

GO:0140096

GO:1900273

GO:1901185

GO:1904646

GO:2001028

HMNXSV003051618

ILMN_1698019

ILMN_2253017

ILMN_2332964

PH_hs_0040329

TC14001451.hg

g1890049_3p_at

Other forms of this molecule

LGMN [endolysosome lumen]

Inferred To

LGMN [lysosomal lumen] (Bos taurus)

LGMN [lysosomal lumen] (Canis familiaris)

LGMN [lysosomal lumen] (Sus scrofa)

lgmn [lysosomal lumen] (Danio rerio)

Lgmn [lysosomal lumen] (Mus musculus)

Lgmn [lysosomal lumen] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2380

OpenTargets

ENSG00000100600

ENSEMBL

ENSP00000334052, ENST00000393218, ENST00000555699, ENSP00000452572, ENSP00000376911, ENST00000334869, ENST00000557434, ENSG00000100600, ENSP00000451861

ZINC - Substances

LGMN_HUMAN

ZINC target

Q99538

PRO

Q99538

GlyGen

Q99538

PDB

4N6O, 5LU9, 8AE4, 4AW9, 5LU8, 8AE5, 4AWA, 4FGU, 7FQK, 7FQL, 5LUB, 5LUA, 7FQJ, 7FQI, 7O50, 4N6N, 4AWB, 7FQH

IntEnz

3.4.22.34

HPA

ENSG00000100600-LGMN

GeneCards

LGMN

Pharos - Targets

Q99538

ZINC - Predictions - Purchasable

LGMN_HUMAN

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14554 PDIA5	1	PDIA5 [endoplasmic reticulum membrane] (R-HSA-535514)	0.527	2
UniProt:P59665 DEFA1	9	DEFA1(1-94) [Golgi lumen] (R-HSA-1467215) DEFA1(20-94) [Golgi lumen] (R-HSA-1467282) DEFA1(66-94) [Golgi lumen] (R-HSA-975663) DEFA1(20-65) [Golgi lumen] (R-HSA-8864970) DEFA1(66-94) [extracellular region] (R-HSA-1461998) DEFA1(66-94) [azurophil granule lumen] (R-HSA-1470038) DEFA1(65-94) [extracellular region] (R-HSA-1462022) omega-N-(ADP-ribosyl)-L-arginine-DEFA1(65-94) [extracellular region] (R-HSA-1972397) DEFA1(65-94) [azurophil granule lumen] (R-HSA-1470053)	0.527	2
UniProt:O95352 ATG7	14	ATG7 [cytosol] (R-HSA-947867) CysO572-ATG7 [cytosol] (R-HSA-5683584) CysO572-ATG7-GARABAPL3 [cytosol] (R-HSA-9820420) CysO572-ATG7-MAP1LC3A [cytosol] (R-HSA-9820421) CysO572-ATG7-MAP1LC3C [cytosol] (R-HSA-9820407) CysO572-ATG7-GARABAPL1 [cytosol] (R-HSA-9820406) CysO572-ATG7-GARABAP [cytosol] (R-HSA-9820417) CysO572-ATG7-GARABAPL2 [cytosol] (R-HSA-9820413) CysO572-ATG7-MAP1LC3B [cytosol] (R-HSA-9820410) ATG7(1-693)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802517) ATG7(1-693)-BRAF(381-766) fusion [cytosol] (R-HSA-6802272) ATG7 [ficolin-1-rich granule lumen] (R-HSA-6801293) ATG7 [extracellular region] (R-HSA-6806451) ATG7 [secretory granule lumen] (R-HSA-6801316)	0.527	2