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ITPR1 [platelet dense tubular network membrane]
Stable Identifier
R-HSA-3325593
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
platelet dense tubular network membrane
Synonyms
Inositol 1,4,5-trisphosphate receptor type 1, ITPR1_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
cGMP effects (Homo sapiens)
PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release (Homo sapiens)
IRAG:ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
Phosphorylated IRAG:IP3 receptor type 1 [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Effects of PIP2 hydrolysis (Homo sapiens)
Binding of IP3 to IP3 receptor (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol (Homo sapiens)
IP3R tetramer:I(1,4,5)P3:4xCa2+ [platelet dense tubular network membrane] (Homo sapiens)
IP3R tetramer [platelet dense tubular network membrane] (Homo sapiens)
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14643 ITPR1
Gene Names
ITPR1, INSP3R1
Chain
chain:1-2758
Reference Genes
BioGPS Gene:3708 ITPR1
COSMIC (genes):ITPR1 ITPR1
CTD Gene:3708 ITPR1
dbSNP Gene:3708 ITPR1
ENSEMBL:ENSG00000150995 ITPR1
ENSEMBL_homo_sapiens_GENE:ENSG00000150995.21 ITPR1
HGNC:6180 ITPR1
KEGG Gene (Homo sapiens):3708 ITPR1
Monarch:3708 ITPR1
NCBI Gene:3708 ITPR1
OMIM:147265 ITPR1
UCSC:Q14643 ITPR1
Reference Transcript
RefSeq:NM_001099952.2 ITPR1
RefSeq:XM_011533683.2 ITPR1
RefSeq:NM_001168272.1 ITPR1
RefSeq:NM_002222.5 ITPR1
Other Identifiers
11739563_a_at
11739564_s_at
11750654_s_at
16936947
203710_PM_at
203710_at
211323_PM_s_at
211323_s_at
216944_PM_s_at
216944_s_at
2608474
2608475
2608477
2608482
2608485
2608511
2608517
2608519
2608520
2608522
2608523
2608525
2608526
2608534
2608536
2608538
2608539
2608540
2608541
2608543
2608545
2608546
2608550
2608551
2608552
2608553
2608555
2608557
2608558
2608559
2608563
2608567
2608568
2608569
2608570
2608571
2608572
2608573
2608576
2608577
2608578
2608580
2608583
2608585
2608589
2608600
2608602
2608608
2608610
2608611
2608612
2608628
2608629
2608630
2608636
2608638
2608641
2608642
2608643
2608644
2608645
2608647
2608649
2608651
2608658
2608659
2608660
2608662
2608663
2608671
2608676
2608677
32778_at
32779_s_at
3448302
3708
73065_at
755_at
8077376
A_14_P115506
A_14_P138843
A_23_P92042
D26070_at
GE63006
GO:0000902
GO:0001666
GO:0005215
GO:0005216
GO:0005220
GO:0005262
GO:0005509
GO:0005515
GO:0005634
GO:0005635
GO:0005637
GO:0005730
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0005955
GO:0006811
GO:0006816
GO:0006914
GO:0006915
GO:0007165
GO:0007200
GO:0007207
GO:0008289
GO:0009791
GO:0010506
GO:0012501
GO:0012505
GO:0014069
GO:0015085
GO:0015278
GO:0016020
GO:0016529
GO:0019722
GO:0019855
GO:0019904
GO:0023052
GO:0030658
GO:0030667
GO:0031088
GO:0031094
GO:0031095
GO:0031410
GO:0032024
GO:0032469
GO:0032991
GO:0034220
GO:0035091
GO:0042045
GO:0043226
GO:0043231
GO:0045202
GO:0048471
GO:0048856
GO:0050849
GO:0050877
GO:0050882
GO:0051209
GO:0055065
GO:0055085
GO:0070059
GO:0070588
GO:0070679
GO:0098685
GO:0098695
GO:0098772
GO:0099105
GO:0099566
GO:1990806
HMNXSV003005605
Hs.198443.2.S1_3p_a_at
ILMN_1789505
PH_hs_0022668
TC03000013.hg
U23850_s_at
g10835022_3p_at
g1464750_3p_a_at
Participates
as a component of
Phosphorylated IRAG:IP3 receptor type 1 [platelet dense tubular network membrane] (Homo sapiens)
IRAG:ITPR1 [platelet dense tubular network membrane] (Homo sapiens)
as a member of
IP3R subunits [platelet dense tubular network membrane] (Homo sapiens)
Other forms of this molecule
ITPR1 [endoplasmic reticulum membrane]
Inferred To
ITPR1 [platelet dense tubular network membrane]
(Bos taurus)
ITPR1 [platelet dense tubular network membrane]
(Caenorhabditis elegans)
ITPR1 [platelet dense tubular network membrane]
(Canis familiaris)
ITPR1 [platelet dense tubular network membrane]
(Dictyostelium discoideum)
ITPR1 [platelet dense tubular network membrane]
(Drosophila melanogaster)
ITPR1 [platelet dense tubular network membrane]
(Gallus gallus)
ITPR1 [platelet dense tubular network membrane]
(Mus musculus)
ITPR1 [platelet dense tubular network membrane]
(Rattus norvegicus)
ITPR1 [platelet dense tubular network membrane]
(Sus scrofa)
Cross References
RefSeq
XP_011531985.1
,
NP_002213.5
,
NP_001093422.2
,
NP_001161744.1
Guide to Pharmacology - Targets
743
OpenTargets
ENSG00000150995
GeneCards
Q14643
HPA
ENSG00000150995-ITPR1
ZINC target
Q14643
Ensembl
ENST00000649015
,
ENSP00000401671
,
ENSP00000497026
,
ENSP00000349597
,
ENST00000357086
,
ENSP00000397885
,
ENSP00000497605
,
ENST00000443694
,
ENST00000456211
,
ENSG00000150995
,
ENST00000648309
PRO
Q14643
Pharos - Targets
Q14643
Orphanet
17412
HMDB Protein
HMDBP02849
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31749 AKT1
13
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.536
2
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