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TAS2R4 [plasma membrane]
Stable Identifier
R-HSA-3299613
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Taste receptor type 2 member 4, TA2R4_HUMAN
Locations in the PathwayBrowser
Expand all
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
Bitter compound binds bitter taste receptor (TAS2R) (Homo sapiens)
TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R4:ligand [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
GNAT3 exchanges GDP for GTP in TAS2R:bitter compound:GNAT3:GDP:GNB1,3:GNG13 (Homo sapiens)
TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R4:ligand [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R4:ligand [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
TAS2R:bitter compound:GNAT3:GTP:GNB1,3:GNG13 dissociates yielding (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R4:ligand [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
TAS2R:ligand:GNAT3:GTP:GNB1,3:GNG13 [plasma membrane] (Homo sapiens)
TAS2R (non-orphan):ligand [plasma membrane] (Homo sapiens)
TAS2R4:ligand [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
T2Rs bind bitter-tasting compounds (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
TAS2R4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYW5 TAS2R4
Gene Names
TAS2R4
Chain
chain:1-299
Reference Genes
BioGPS Gene:50832 TAS2R4
COSMIC (genes):TAS2R4 TAS2R4
CTD Gene:50832 TAS2R4
dbSNP Gene:50832 TAS2R4
ENSEMBL:ENSG00000127364 TAS2R4
HGNC:14911 TAS2R4
KEGG:hsa:50832 TAS2R4
Monarch:50832 TAS2R4
NCBI Gene:50832 TAS2R4
OMIM:604869 TAS2R4
UCSC:Q9NYW5 TAS2R4
Reference Transcript
RefSeq:NM_016944.1 TAS2R4
Other Identifiers
11737668_at
17052417
221392_PM_at
221392_at
3027955
3027957
3027958
3027959
3027960
50832
8136645
ADDON002529.hg
A_14_P134356
A_23_P20101
GE79701
GO:0001580
GO:0004930
GO:0005886
GO:0005929
GO:0007165
GO:0007186
GO:0007585
GO:0008527
GO:0016020
GO:0033038
GO:0043226
GO:0050877
GO:0050909
GO:0060089
GO:0060170
HMNXSV003052058
ILMN_1745038
PH_hs_0026760
PH_hs_0036120
TC07000894.hg
g8394401_3p_at
Participates
as a member of
TAS2R (non-orphan) [plasma membrane] (Homo sapiens)
TAS2Rs [plasma membrane] (Homo sapiens)
as a component of
TAS2R4:ligand [plasma membrane] (Homo sapiens)
Inferred To
TAS2R4 [plasma membrane]
(Bos taurus)
TAS2R4 [plasma membrane]
(Canis familiaris)
TAS2R4 [plasma membrane]
(Sus scrofa)
t2r14 [plasma membrane]
(Xenopus tropicalis)
t2r2 [plasma membrane]
(Xenopus tropicalis)
Tas2r4 [plasma membrane]
(Mus musculus)
Tas2r4 [plasma membrane]
(Rattus norvegicus)
Homologues of TAS2R19 [plasma membrane]
(Danio rerio)
Homologues of TAS2R19 [plasma membrane]
(Gallus gallus)
Homologues of TAS2R19 [plasma membrane]
(Xenopus tropicalis)
t2r3 [plasma membrane]
(Xenopus tropicalis)
TAS2R7 [plasma membrane]
(Gallus gallus)
tas2r200.1 [plasma membrane]
(Danio rerio)
tas2r7 [plasma membrane]
(Xenopus tropicalis)
TAS2R40 [plasma membrane]
(Gallus gallus)
t2r15 [plasma membrane]
(Xenopus tropicalis)
tas2r4 [plasma membrane]
(Xenopus tropicalis)
tas2r200.2 [plasma membrane]
(Danio rerio)
LOC101747503 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_058640.1
Guide to Pharmacology - Targets
661
ENSEMBL
ENST00000247881
,
ENSP00000247881
OpenTargets
ENSG00000127364
HPA
ENSG00000127364-TAS2R4
ZINC - Substances
TA2R4_HUMAN
ZINC target
Q9NYW5
PRO
Q9NYW5
Pharos - Targets
Q9NYW5
GlyGen
Q9NYW5
HMDB Protein
HMDBP08042
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