Reactome | TAS2R4 [plasma membrane]

TAS2R4 [plasma membrane]

Stable Identifier

R-BTA-3299613

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

TAS2R4, Q2ABC3

Locations in the PathwayBrowser

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Sensory Perception (Bos taurus)

- Sensory perception of taste (Bos taurus)
  - Sensory perception of sweet, bitter, and umami (glutamate) taste (Bos taurus)
    - Bitter compound binds bitter taste receptor (TAS2R) (Bos taurus)
      - TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Bos taurus)
        
        TAS2R (non-orphan) [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
      - TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Bos taurus)
        
        TAS2R (non-orphan):ligand [plasma membrane] (Bos taurus)
        
        TAS2R4:ligand [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)

Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (i) signalling events (Bos taurus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
      - The Ligand:GPCR:Gi complex dissociates (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Bos taurus)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
  - GPCR ligand binding (Bos taurus)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Bos taurus)
      - T2Rs bind bitter-tasting compounds (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Bos taurus)
        
        TAS2Rs [plasma membrane] (Bos taurus)
        
        TAS2R4 [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:Q2ABC3

Gene Names

TAS2R4

Reference Genes

BioGPS Gene:664648 TAS2R4

ENSEMBL:ENSBTAG00000018440.4

KEGG:bta:664648 TAS2R4

Monarch:664648 TAS2R4

NCBI Gene:664648 TAS2R4

UCSC:Q2ABC3 TAS2R4

Reference Transcript

RefSeq:NM_001046635.1 TAS2R4

Other Identifiers

664648

GO:0001580

GO:0004930

GO:0007186

GO:0007585

GO:0016020

GO:0033038

GO:0050877

GO:0050909

Participates

as a member of

as a component of

TAS2R4:ligand [plasma membrane] (Bos taurus)

Inferred From

TAS2R4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001040100.1

ENSEMBL

ENSBTAT00000024537, ENSBTAG00000018440, ENSBTAP00000024537

VGNC

35613