Reactome | TAS2R4 [plasma membrane]

TAS2R4 [plasma membrane]

Stable Identifier

R-CFA-3299613

Type

Protein [EntityWithAccessionedSequence]

Species

Canis familiaris

Compartment

plasma membrane

Synonyms

TAS2R4, A0A8I3SCV7

Locations in the PathwayBrowser

Expand all

Sensory Perception (Canis familiaris)

- Sensory perception of taste (Canis familiaris)
  - Sensory perception of sweet, bitter, and umami (glutamate) taste (Canis familiaris)
    - Bitter compound binds bitter taste receptor (TAS2R) (Canis familiaris)
      - TAS2R:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Canis familiaris)
        
        TAS2R (non-orphan) [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
      - TAS2R:ligand:GNAT3:GDP:GNB1,3:GNG13 [plasma membrane] (Canis familiaris)
        
        TAS2R (non-orphan):ligand [plasma membrane] (Canis familiaris)
        
        TAS2R4:ligand [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)

Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
  - GPCR ligand binding (Canis familiaris)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Canis familiaris)
      - T2Rs bind bitter-tasting compounds (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Canis familiaris)
        
        TAS2Rs [plasma membrane] (Canis familiaris)
        
        TAS2R4 [plasma membrane] (Canis familiaris)

External Reference Information

External Reference

UniProt:A0A8I3SCV7

Gene Names

TAS2R4

Reference Genes

BioGPS Gene:100688996 TAS2R4

ENSEMBL:ENSCAFG00845030928.1

KEGG:cfa:100688996 TAS2R4

Monarch:100688996 TAS2R4

NCBI Gene:100688996 TAS2R4

UCSC:A0A8I3SCV7 TAS2R4

Reference Transcript

Other Identifiers

100688996

GO:0001580

GO:0004930

GO:0007165

GO:0007186

GO:0007585

GO:0016020

GO:0033038

GO:0050877

GO:0050909

Participates

as a member of

as a component of

TAS2R4:ligand [plasma membrane] (Canis familiaris)

Inferred From

TAS2R4 [plasma membrane] (Homo sapiens)

Cross References

RefSeq

XP_003639608.2, XP_038415299.1, XP_038544997.1

ENSEMBL

ENSCAFG00845030928, ENSCAFP00845043224, ENSCAFT00845054971