WLS is endocytosed to the early endosome

Stable Identifier
Reaction [omitted]
Homo sapiens
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WLS endocytosis is a clathrin-dependent process. In Drosophila cells, internalization of WLS has been shown to depend on clathrin, AP-2, dynamin, Rab5 and HRS (Belenkaya et al, 2006; Port et al, 2008), while in HeLa cells, WLS colocalizes with endogenous AP-2, and depletion of AP-2 increases WLS levels at the cell surface (Yang et al, 2008). A recent study identified a conserved YEGL endocytosis motif in the third intracellular loop of WLS that is required for its clathrin- and dynamin-dependent internalization (Gasnereau et al, 2011).

Literature References
PubMed ID Title Journal Year
18160348 The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

Lin, X, Yan, D, Cheng, L, Selva, EM, Zhou, B, Tang, X, Sharma, YV, Belenkaya, TY, Wu, Y

Dev. Cell 2008
18193032 Wingless secretion promotes and requires retromer-dependent cycling of Wntless

Herr, P, Furger, E, Bänziger, C, Port, F, Kuster, M, Hausmann, G, Basler, K

Nat. Cell Biol. 2008
18160347 Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells

Korswagen, HC, Yang, PT, Betist, MC, Lorenowicz, MJ, Coudreuse, DY, Silhankova, M

Dev. Cell 2008
22027831 Identification of an endocytosis motif in an intracellular loop of Wntless protein, essential for its recycling and the control of Wnt protein signaling

Herr, P, Gasnereau, I, Chia, PZ, Basler, K, Gleeson, PA

J. Biol. Chem. 2011
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