WLS endocytosis is a clathrin-dependent process. In Drosophila cells, internalization of WLS has been shown to depend on clathrin, AP-2, dynamin, Rab5 and HRS (Belenkaya et al, 2006; Port et al, 2008), while in HeLa cells, WLS colocalizes with endogenous AP-2, and depletion of AP-2 increases WLS levels at the cell surface (Yang et al, 2008). A recent study identified a conserved YEGL endocytosis motif in the third intracellular loop of WLS that is required for its clathrin- and dynamin-dependent internalization (Gasnereau et al, 2011).
Port, F, Kuster, M, Herr, P, Furger, E, Bänziger, C, Hausmann, G, Basler, K
Belenkaya, TY, Wu, Y, Tang, X, Zhou, B, Cheng, L, Sharma, YV, Yan, D, Selva, EM, Lin, X
Yang, PT, Lorenowicz, MJ, Silhankova, M, Coudreuse, DY, Betist, MC, Korswagen, HC
Gasnereau, I, Herr, P, Chia, PZ, Basler, K, Gleeson, PA
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