Reactome | WLS is endocytosed to the early endosome

WLS is endocytosed to the early endosome

Stable Identifier

R-HSA-3247847

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

early endosome membrane, plasma membrane

ReviewStatus

5/5

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WLS is endocytosed to the early endosome

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WLS endocytosis is a clathrin-dependent process. In Drosophila cells, internalization of WLS has been shown to depend on clathrin, AP-2, dynamin, Rab5 and HRS (Belenkaya et al, 2006; Port et al, 2008), while in HeLa cells, WLS colocalizes with endogenous AP-2, and depletion of AP-2 increases WLS levels at the cell surface (Yang et al, 2008). A recent study identified a conserved YEGL endocytosis motif in the third intracellular loop of WLS that is required for its clathrin- and dynamin-dependent internalization (Gasnereau et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
18160348	The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network Belenkaya, TY, Wu, Y, Tang, X, Zhou, B, Cheng, L, Sharma, YV, Yan, D, Selva, EM, Lin, X	Dev. Cell	2008
18193032	Wingless secretion promotes and requires retromer-dependent cycling of Wntless Port, F, Kuster, M, Herr, P, Furger, E, Bänziger, C, Hausmann, G, Basler, K	Nat. Cell Biol.	2008
18160347	Wnt signaling requires retromer-dependent recycling of MIG-14/Wntless in Wnt-producing cells Yang, PT, Lorenowicz, MJ, Silhankova, M, Coudreuse, DY, Betist, MC, Korswagen, HC	Dev. Cell	2008
22027831	Identification of an endocytosis motif in an intracellular loop of Wntless protein, essential for its recycling and the control of Wnt protein signaling Gasnereau, I, Herr, P, Chia, PZ, Basler, K, Gleeson, PA	J. Biol. Chem.	2011