WLS endocytosis is a clathrin-dependent process. In Drosophila cells, internalization of WLS has been shown to depend on clathrin, AP-2, dynamin, Rab5 and HRS (Belenkaya et al, 2006; Port et al, 2008), while in HeLa cells, WLS colocalizes with endogenous AP-2, and depletion of AP-2 increases WLS levels at the cell surface (Yang et al, 2008). A recent study identified a conserved YEGL endocytosis motif in the third intracellular loop of WLS that is required for its clathrin- and dynamin-dependent internalization (Gasnereau et al, 2011).
Lin, X, Yan, D, Cheng, L, Selva, EM, Zhou, B, Tang, X, Sharma, YV, Belenkaya, TY, Wu, Y
Herr, P, Furger, E, Bänziger, C, Port, F, Kuster, M, Hausmann, G, Basler, K
Korswagen, HC, Yang, PT, Betist, MC, Lorenowicz, MJ, Coudreuse, DY, Silhankova, M
Herr, P, Gasnereau, I, Chia, PZ, Basler, K, Gleeson, PA
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