ERF binds ETS2 promoter

Stable Identifier
R-HSA-3209177
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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ERF binds ETS2 promoter
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ERF binds to an ETS-binding site in the ETS2 promoter (Sgouras et al. 1995). Phosphorylation of ERF by activated MAPK1 (ERK2) or MAPK3 (ERK1) interferes with ERF-mediated upregulation of ETS2 (Le Gallic et al. 2004).

Literature References
PubMed ID Title Journal Year
7588608 ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation

Sgouras, DN, Athanasiou, MA, Beal, GJ, Fisher, RJ, Blair, DG, Mavrothalassitis, GJ

EMBO J. 1995
14729966 ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

Le Gallic, L, Virgilio, L, Cohen, P, Biteau, B, Mavrothalassitis, G

Mol. Cell. Biol. 2004
Participants
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Output
Participant Of
hasEvent
This event is regulated
Negatively by
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-02)
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