ERF binds ETS2 promoter

Stable Identifier
R-HSA-3209177
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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ERF binds ETS2 promoter
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ERF binds to an ETS-binding site in the ETS2 promoter (Sgouras et al. 1995). Phosphorylation of ERF by activated MAPK1 (ERK2) or MAPK3 (ERK1) interferes with ERF-mediated upregulation of ETS2 (Le Gallic et al. 2004).

Literature References
PubMed ID Title Journal Year
14729966 ERF nuclear shuttling, a continuous monitor of Erk activity that links it to cell cycle progression

Cohen, P, Mavrothalassitis, G, Le Gallic, L, Biteau, B, Virgilio, L

Mol. Cell. Biol. 2004
7588608 ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation

Mavrothalassitis, GJ, Fisher, RJ, Blair, DG, Athanasiou, MA, Beal, GJ, Sgouras, DN

EMBO J. 1995
Participants
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Output
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as an event of
This event is regulated
Negatively by
Regulator
p-T,Y MAPK dimers [nucleoplasm] (Homo sapiens)
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-01)
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