Reactome | Transport of GAG to the Plasma Membrane

Transport of GAG to the Plasma Membrane

Stable Identifier

R-HSA-3149434

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - HIV Life Cycle (Homo sapiens)
        
        Late Phase of HIV Life Cycle (Homo sapiens)
        
        Assembly Of The HIV Virion (Homo sapiens)
        
        Synthesis And Processing Of GAG, GAGPOL Polyproteins (Homo sapiens)
        
        Membrane binding and targetting of GAG proteins (Homo sapiens)
        
        Transport of GAG to the Plasma Membrane (Homo sapiens)

General

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Assembling Gag molecules are largely derived from the rapidly diffusing cytoplasmic pool. Gag membrane targeting requires myristoylation and a subset of GAG molecules are shuttled to the plasma membrane in this way.

Literature References

PubMed ID	Title	Journal	Year
21289126	Gag localization and virus-like particle release mediated by the matrix domain of human T-lymphotropic virus type 1 Gag are less dependent on phosphatidylinositol-(4,5)-bisphosphate than those mediated by the matrix domain of HIV-1 Gag Inlora, J, Chukkapalli, V, Derse, D, Ono, A	J. Virol.	2011

Participants

Input

monoubiquitinated N-myristoyl GAG (P04591) protein [endosome membrane] (Homo sapiens)

Output

monoubiquitinated N-myristoyl GAG (P04591) protein [plasma membrane] (Homo sapiens)

Participates

as an event of

Membrane binding and targetting of GAG proteins (Homo sapiens)

Catalyst Activity

protein transmembrane transporter activity of ESCRT-I [endosome membrane]

Physical Entity

ESCRT-I [endosome membrane] (Homo sapiens)

Activity

protein transmembrane transporter activity (GO:0008320)

Disease

Name	Identifier	Synonyms
Human immunodeficiency virus infectious disease	DOID:526	HIV infection

Cross References

Mondo

0005109

Authored

Gillespie, ME (2013-03-07)

Reviewed

Dube, M (2013-05-21)

Created

Gillespie, ME (2013-02-14)

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