Membrane binding and targetting of GAG proteins

Stable Identifier
R-HSA-174490
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1
ReviewStatus
5/5
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Membrane binding and targetting of GAG proteins
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One of the mysteries of Gag protein involvement in HIV virion assembly is how the proteins are targeted to the proper membrane for budding. Infectious retroviruses do not bud from all of the available membrane surfaces within an infected cell, but primarily from the plasma membrane, which constitutes a small proportion of the total membrane surface in most cells. In polarized cells, the sites of budding are further restricted to the basolateral membrane.
Literature References
PubMed ID Title Journal Year
16683918 Identification of an intracellular trafficking and assembly pathway for HIV-1 gag

Resh, MD, Perlman, M

Traffic 2006
15473846 Retrovirus budding

Sundquist, WI, Morita, E

Annu Rev Cell Dev Biol 2004
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
intracellular transport of virus (0075733)
Disease
Name Identifier Synonyms
Human immunodeficiency virus infectious disease DOID:526 HIV infection
Cross References
BioModels Database
Authored
Gillespie, ME  (2013-03-07)
Reviewed
Dube, M  (2013-05-21)
Created
Gopinathrao, G  (2006-02-18)
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