Reactome | PVRL1 [plasma membrane]

PVRL1 [plasma membrane]

Stable Identifier

R-HSA-3008842

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Poliovirus receptor-related protein 1, PVRL1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q15223 NECTIN1

Gene Names

NECTIN1, HVEC, PRR1, PVRL1

Chain

signal peptide:1-30, chain:31-517

Reference Genes

BioGPS Gene:5818 NECTIN1

COSMIC - genes:NECTIN1 NECTIN1

CTD Gene:5818 NECTIN1

dbSNP Gene:5818 NECTIN1

ENSEMBL:ENSG00000110400 NECTIN1

HGNC:9706 NECTIN1

KEGG:hsa:5818 NECTIN1

Monarch:5818 NECTIN1

NCBI Gene:5818 NECTIN1

OMIM:600644 NECTIN1

UCSC:Q15223 NECTIN1

Reference Transcript

Other Identifiers

11718813_a_at

11718814_x_at

11718815_at

11738866_a_at

208455_PM_at

208455_at

211845_PM_at

211845_at

211846_PM_s_at

211846_s_at

225211_PM_at

225211_at

3394489

3394490

3394491

3394493

3394494

3394495

3394496

3394497

3394498

3394499

3394500

3394506

3394507

3394508

3394509

3394510

3394511

3394512

3394513

3394515

3394516

3394518

3394519

3394520

3394522

3394523

3394528

3394541

3394542

3394543

34999_at

43412_s_at

5818

62287_at

65876_at

7952274

A_23_P76034

A_24_P50890

GE54555

GO:0001618

GO:0002089

GO:0002376

GO:0002934

GO:0005515

GO:0005576

GO:0005886

GO:0005912

GO:0006826

GO:0006955

GO:0007155

GO:0007156

GO:0007157

GO:0007411

GO:0015026

GO:0016020

GO:0030246

GO:0030424

GO:0030425

GO:0032584

GO:0034330

GO:0038023

GO:0042734

GO:0042802

GO:0042803

GO:0042995

GO:0043296

GO:0044291

GO:0044877

GO:0045202

GO:0046718

GO:0046790

GO:0048593

GO:0048787

GO:0048856

GO:0050807

GO:0050839

GO:0051963

GO:0060041

GO:0070161

GO:0070166

GO:0090103

GO:0098609

GO:0098631

GO:0098686

GO:1902414

HMNXSV003047074

Hs.4213.0.A1_3p_at

Hs.4213.0.A1_3p_x_at

ILMN_1691295

ILMN_1695549

ILMN_1720076

ILMN_1744815

PH_hs_0000464

PH_hs_0027382

TC11002372.hg

g11602905_3p_at

g4154345_3p_at

Participates

as a component of

as an input of

Necl-1:Nectin-1 trans heterodimer interaction (Homo sapiens)

as a member of

Nectin [plasma membrane] (Homo sapiens)

Inferred To

NECTIN1 [plasma membrane] (Bos taurus)

NECTIN1 [plasma membrane] (Canis familiaris)

NECTIN1 [plasma membrane] (Gallus gallus)

NECTIN1 [plasma membrane] (Sus scrofa)

Nectin1 [plasma membrane] (Mus musculus)

Nectin1 [plasma membrane] (Rattus norvegicus)

him-4 [plasma membrane] (Caenorhabditis elegans)

Fas3 [plasma membrane] (Drosophila melanogaster)

nectin1 [plasma membrane] (Xenopus tropicalis)

nectin1b [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_976031.1, NP_976030.1, NP_002846.3

OpenTargets

ENSG00000110400

ENSEMBL

ENST00000264025, ENSP00000264025, ENSP00000345289, ENST00000340882, ENSG00000110400

HPA

ENSG00000110400-NECTIN1

GeneCards

NECTIN1

PRO

Q15223

Pharos - Targets

Q15223

Orphanet

NECTIN1

GlyGen

Q15223

PDB

3U82, 4MYW, 4FMF, 3U83, 3ALP, 3SKU

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15223 NECTIN1	1	PVRL1 [plasma membrane] (R-HSA-3008842)	0.838	6
UniProt:Q9NQS3 NECTIN3	1	PVRL3 [plasma membrane] (R-HSA-449762)	0.835	7
UniProt:Q96NY8 NECTIN4	1	PVRL4 [plasma membrane] (R-HSA-198159)	0.756	6
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.65	8
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.592	2
UniProt:Q9C0E4 GRIP2	2	GRIP2 [plasma membrane] (R-HSA-416632) GRIP2 [cytosol] (R-HSA-416643)	0.592	6
UniProt:Q14168 MPP2			0.59	2
UniProt:Q9NQS3-1 NECTIN3			0.558	3
UniProt:Q92520 FAM3C	2	FAM3C [platelet dense granule lumen] (R-HSA-8848884) FAM3C [extracellular region] (R-HSA-8848922)	0.556	3
UniProt:O00214 LEG8			0.527	2
IntAct:EBI-1771356 VGLD			0.524	2
UniProt:Q62083	2	PICK1 [endocytic vesicle membrane] (R-MMU-417017) PICK1 [plasma membrane] (R-MMU-416989)	0.463	2