MBD4 glycosylase mediated recognition and binding of an uracil opposite to a guanine at CpG sequences

Stable Identifier
R-HSA-110171
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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MBD4 (MED1; methyl-CpG-binding domain protein 4) recognizes and binds uracil mispaired with guanine at non-methylated CpG islands. G:U mispairs are generated by oxidative deamination of cytosine (Petronzelli et al. 2000).

Literature References
PubMed ID Title Journal Year
11056019 Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain

Petronzelli, F, Riccio, A, Markham, GD, Seeholzer, SH, Genuardi, M, Karbowski, M, Yeung, AT, Matsumoto, Y, Bellacosa, A

J. Cell. Physiol. 2000
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