Reactome | TOPORS [nucleoplasm]

TOPORS [nucleoplasm]

Stable Identifier

R-HSA-2993791

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

E3 ubiquitin-protein ligase Topors ecNumber6.3.2.-/ecNumber, TOPRS_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NS56 TOPORS

Gene Names

TOPORS, LUN, TP53BPL

Chain

chain:1-1045

Reference Genes

BioGPS Gene:10210 TOPORS

COSMIC (genes):TOPORS TOPORS

CTD Gene:10210 TOPORS

dbSNP Gene:10210 TOPORS

ENSEMBL:ENSG00000197579 TOPORS

ENSEMBL_homo_sapiens_GENE:ENSG00000197579.8 TOPORS

HGNC:21653 TOPORS

KEGG Gene (Homo sapiens):10210 TOPORS

Monarch:10210 TOPORS

NCBI Gene:10210 TOPORS

OMIM:609507 TOPORS

UCSC:Q9NS56 TOPORS

Reference Transcript

Other Identifiers

10210

11732260_a_at

17093117

204071_PM_s_at

204071_s_at

3203136

3203137

3203138

3203139

3203140

3203141

3203142

3203143

3203144

3203145

3203146

3203147

3203148

3203149

3203150

3203154

3203157

3203158

3203159

38568_at

8160581

A_23_P32217

GE58383

GO:0000151

GO:0000209

GO:0000922

GO:0000930

GO:0003677

GO:0003823

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005654

GO:0005814

GO:0005815

GO:0005856

GO:0005929

GO:0006351

GO:0006355

GO:0006511

GO:0006513

GO:0006974

GO:0008630

GO:0010842

GO:0012501

GO:0016605

GO:0016607

GO:0016740

GO:0016925

GO:0019789

GO:0023052

GO:0030154

GO:0030163

GO:0030496

GO:0032391

GO:0034504

GO:0035845

GO:0036064

GO:0036211

GO:0042127

GO:0042771

GO:0043066

GO:0043161

GO:0043226

GO:0044547

GO:0045893

GO:0046548

GO:0046549

GO:0046872

GO:0048856

GO:0051443

GO:0051457

GO:0061630

GO:0070936

GO:0140096

HMNXSV003024074

ILMN_1749218

ILMN_2122669

PH_hs_0026080

TC09001000.hg

g5032190_3p_a_at

Participates

as an input of

SUMOylation of TOPORS with SUMO1 (Homo sapiens)

Other forms of this molecule

monoSUMO1-K560-TOPORS [nucleoplasm]

Inferred To

topors [nucleoplasm] (Xenopus tropicalis)

TOPORS [nucleoplasm] (Bos taurus)

TOPORS [nucleoplasm] (Canis familiaris)

TOPORS [nucleoplasm] (Dictyostelium discoideum)

TOPORS [nucleoplasm] (Gallus gallus)

TOPORS [nucleoplasm] (Sus scrofa)

Topors [nucleoplasm] (Drosophila melanogaster)

Topors [nucleoplasm] (Mus musculus)

Topors [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001182551.1, NP_005793.2

OpenTargets

ENSG00000197579

GeneCards

Q9NS56

HPA

ENSG00000197579-TOPORS

Ensembl

ENSG00000197579, ENST00000360538, ENST00000379858, ENSP00000353735, ENSP00000369187

PRO

Q9NS56

Pharos - Targets

Q9NS56

HMDB Protein

HMDBP09258

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.547	2
UniProt:Q8N393 ZNF786	1	ZNF786 [nucleoplasm] (R-HSA-3323088)	0.527	2
UniProt:Q969T4 UBE2E3	4	UBE2E3 [cytosol] (R-HSA-947633) UBE2E3 [nucleoplasm] (R-HSA-8852108) Ub-C145-UBE2E3 [nucleoplasm] (R-HSA-8864208) Ub-C145-UBE2E3 [cytosol] (R-HSA-8864162)	0.527	2
UniProt:Q9BPZ2 SPI2B			0.527	2
UniProt:Q9H307 PNN	1	PNN [nucleoplasm] (R-HSA-9770779)	0.527	2
UniProt:Q86VM9 ZCH18			0.527	3
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.527	2
UniProt:Q6AW86 ZNF324B	1	ZNF324B [nucleoplasm] (R-HSA-3323092)	0.527	2
UniProt:Q9Y657 SPIN1			0.527	3
UniProt:O14978 ZNF263	1	ZNF263 [nucleoplasm] (R-HSA-1027393)	0.527	2
UniProt:Q0VGE8 ZNF816	1	ZNF816 [nucleoplasm] (R-HSA-9843461)	0.527	3
UniProt:Q9BYG3 MK67I			0.527	2
UniProt:Q9UL59 ZNF214	1	ZNF214 [nucleoplasm] (R-HSA-1027353)	0.527	2