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monoSUMO1-K560-TOPORS [nucleoplasm]
Stable Identifier
R-HSA-4551754
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
E3 ubiquitin-protein ligase Topors ecNumber6.3.2.-/ecNumber, TOPRS_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of SUMOylation proteins (Homo sapiens)
SUMOylation of TOPORS with SUMO1 (Homo sapiens)
monoSUMO1-K560-TOPORS [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NS56 TOPORS
Gene Names
TOPORS, LUN, TP53BPL
Chain
chain:1-1045
Reference Genes
BioGPS Gene:10210 TOPORS
COSMIC (genes):TOPORS TOPORS
CTD Gene:10210 TOPORS
dbSNP Gene:10210 TOPORS
ENSEMBL:ENSG00000197579 TOPORS
ENSEMBL_homo_sapiens_GENE:ENSG00000197579.8 TOPORS
HGNC:21653 TOPORS
KEGG Gene (Homo sapiens):10210 TOPORS
Monarch:10210 TOPORS
NCBI Gene:10210 TOPORS
OMIM:609507 TOPORS
UCSC:Q9NS56 TOPORS
Reference Transcript
RefSeq:NM_001195622.1 TOPORS
RefSeq:NM_005802.4 TOPORS
Other Identifiers
10210
11732260_a_at
17093117
204071_PM_s_at
204071_s_at
3203136
3203137
3203138
3203139
3203140
3203141
3203142
3203143
3203144
3203145
3203146
3203147
3203148
3203149
3203150
3203154
3203157
3203158
3203159
38568_at
8160581
A_23_P32217
GE58383
GO:0000151
GO:0000209
GO:0000922
GO:0000930
GO:0003677
GO:0003823
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005814
GO:0005815
GO:0005856
GO:0005929
GO:0006351
GO:0006355
GO:0006511
GO:0006513
GO:0006974
GO:0008630
GO:0010842
GO:0012501
GO:0016605
GO:0016607
GO:0016740
GO:0016925
GO:0019789
GO:0023052
GO:0030154
GO:0030163
GO:0030496
GO:0032391
GO:0034504
GO:0035845
GO:0036064
GO:0036211
GO:0042127
GO:0042771
GO:0043066
GO:0043161
GO:0043226
GO:0044547
GO:0045893
GO:0046548
GO:0046549
GO:0046872
GO:0048856
GO:0051443
GO:0051457
GO:0061630
GO:0070936
GO:0140096
HMNXSV003024074
ILMN_1749218
ILMN_2122669
PH_hs_0026080
TC09001000.hg
g5032190_3p_a_at
Participates
as an output of
SUMOylation of TOPORS with SUMO1 (Homo sapiens)
Other forms of this molecule
TOPORS [nucleoplasm]
Inferred To
monoSUMO1-K560-TOPORS [nucleoplasm]
(Dictyostelium discoideum)
monoSUMO1-K560-TOPORS [nucleoplasm]
(Gallus gallus)
topors [nucleoplasm]
(Xenopus tropicalis)
TOPORS [nucleoplasm]
(Bos taurus)
TOPORS [nucleoplasm]
(Sus scrofa)
Topors [nucleoplasm]
(Mus musculus)
Topors [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 560
Coordinate
560
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001182551.1
,
NP_005793.2
OpenTargets
ENSG00000197579
GeneCards
Q9NS56
HPA
ENSG00000197579-TOPORS
Ensembl
ENSG00000197579
,
ENST00000360538
,
ENST00000379858
,
ENSP00000353735
,
ENSP00000369187
PRO
Q9NS56
Pharos - Targets
Q9NS56
HMDB Protein
HMDBP09258
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P51668 UBE2D1
3
UBE2D1 [cytosol]
(R-HSA-174236)
UBE2D1 [nucleoplasm]
(R-HSA-174197)
Ub-C85-UBE2D1 [cytosol]
(R-HSA-8864160)
0.547
2
UniProt:Q8N393 ZNF786
1
ZNF786 [nucleoplasm]
(R-HSA-3323088)
0.527
2
UniProt:Q969T4 UBE2E3
4
UBE2E3 [cytosol]
(R-HSA-947633)
UBE2E3 [nucleoplasm]
(R-HSA-8852108)
Ub-C145-UBE2E3 [nucleoplasm]
(R-HSA-8864208)
Ub-C145-UBE2E3 [cytosol]
(R-HSA-8864162)
0.527
2
UniProt:Q9BPZ2 SPI2B
0.527
2
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.527
2
UniProt:Q86VM9 ZCH18
0.527
3
UniProt:O94888 WIPF1
2
UBXN7 [cytosol]
(R-HSA-8956071)
ub-UBXN7 [cytosol]
(R-HSA-9755305)
0.527
2
UniProt:Q6AW86 ZNF324B
1
ZNF324B [nucleoplasm]
(R-HSA-3323092)
0.527
2
UniProt:Q9Y657 SPIN1
0.527
3
UniProt:O14978 ZNF263
1
ZNF263 [nucleoplasm]
(R-HSA-1027393)
0.527
2
UniProt:Q0VGE8 ZNF816
1
ZNF816 [nucleoplasm]
(R-HSA-9843461)
0.527
3
UniProt:Q9BYG3 MK67I
0.527
2
UniProt:Q9UL59 ZNF214
1
ZNF214 [nucleoplasm]
(R-HSA-1027353)
0.527
2
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