Activation of NIMA Kinases NEK9, NEK6, NEK7

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

NEK6 and NEK7 are activated during mitosis by another NIMA family kinase, NEK9 (Belham et al. 2003, Richards et al. 2009), which is activated by CDK1- and PLK1-mediated phosphorylation (Roig et al. 2002, Bertran et al. 2011).

Literature References
PubMed ID Title Journal Year
19941817 An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9

Cheung, J, O'Regan, L, Hoelder, S, Richards, MW, Bayliss, R, Fry, AM, Blot, JM, Mas-Droux, C

Mol. Cell 2009
21642957 Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5

Sdelci, S, Bertran, MT, Avruch, J, Roig, J, Caelles, C, Regué, L

EMBO J. 2011
12840024 A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases

Aoyama, Y, Kemp, BE, Avruch, J, Belham, C, Roig, J, Caldwell, JA, Comb, M

J. Biol. Chem. 2003
12101123 Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression

Avruch, J, Belham, C, Roig, J, Mikhailov, A

Genes Dev. 2002
Orthologous Events
Cite Us!