Reactome | Activation of NIMA Kinases NEK9, NEK6, NEK7

Activation of NIMA Kinases NEK9, NEK6, NEK7

Stable Identifier

R-HSA-2980767

DOI

10.3180/REACT_160122.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Activation of NIMA Kinases NEK9, NEK6, NEK7

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NEK6 and NEK7 are activated during mitosis by another NIMA family kinase, NEK9 (Belham et al. 2003, Richards et al. 2009), which is activated by CDK1- and PLK1-mediated phosphorylation (Roig et al. 2002, Bertran et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
19941817	An autoinhibitory tyrosine motif in the cell-cycle-regulated Nek7 kinase is released through binding of Nek9 Richards, MW, O'Regan, L, Mas-Droux, C, Blot, JM, Cheung, J, Hoelder, S, Fry, AM, Bayliss, R	Mol. Cell	2009
21642957	Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5 Bertran, MT, Sdelci, S, Regué, L, Avruch, J, Caelles, C, Roig, J	EMBO J.	2011
12840024	A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases Belham, C, Roig, J, Caldwell, JA, Aoyama, Y, Kemp, BE, Comb, M, Avruch, J	J. Biol. Chem.	2003
12101123	Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression Roig, J, Mikhailov, A, Belham, C, Avruch, J	Genes Dev.	2002