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Nuclear Envelope Breakdown
Stable Identifier
R-HSA-2980766
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
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The nuclear envelope breakdown (NEBD) happens in late prophase of mitosis and involves disassembly of the nuclear pore complex, depolymerization of the nuclear lamina, and clearance of nuclear envelope from chromatin. NEBD allows mitotic spindle microtubules to access condensed chromosomes at kinetochores and enables nuclear division and segregation of genetic material to two daughter cells. For a recent review, please refer to Guttinger et al. 2009.
In mitotic prophase, chromatin detaches from the nuclear envelope, and this contributes to the nuclear envelope breakdown. VRK1 (and possibly VRK2) mediated phosphorylation of BANF1 (BAF), a protein that simultaneously interacts with DNA, LEM-domain inner nuclear membrane proteins, and lamins (Zheng et al. 2000, Shumaker et al. 2001, Haraguchi et al. 2001, Mansharamani and Wilson 2005, Brachner et al. 2005) is considered to be one of the key steps in the detachment of the nuclear envelope from chromatin (Bengtsson and Wilson 2006, Nichols et al. 2006, Gorjanacz et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
19234477
Orchestrating nuclear envelope disassembly and reassembly during mitosis
Güttinger, S
,
Laurell, E
,
Kutay, U
Nat. Rev. Mol. Cell Biol.
2009
Participants
Events
Activation of NIMA Kinases NEK9, NEK6, NEK7
(Homo sapiens)
Nuclear Pore Complex (NPC) Disassembly
(Homo sapiens)
VRK1/VRK2 phosphorylate BANF1
(Homo sapiens)
Depolymerization of the Nuclear Lamina
(Homo sapiens)
Participates
as an event of
Mitotic Prophase (Homo sapiens)
Event Information
Go Biological Process
mitotic nuclear membrane disassembly (0007077)
Orthologous Events
Nuclear Envelope Breakdown (Bos taurus)
Nuclear Envelope Breakdown (Caenorhabditis elegans)
Nuclear Envelope Breakdown (Canis familiaris)
Nuclear Envelope Breakdown (Danio rerio)
Nuclear Envelope Breakdown (Dictyostelium discoideum)
Nuclear Envelope Breakdown (Drosophila melanogaster)
Nuclear Envelope Breakdown (Gallus gallus)
Nuclear Envelope Breakdown (Mus musculus)
Nuclear Envelope Breakdown (Plasmodium falciparum)
Nuclear Envelope Breakdown (Rattus norvegicus)
Nuclear Envelope Breakdown (Saccharomyces cerevisiae)
Nuclear Envelope Breakdown (Schizosaccharomyces pombe)
Nuclear Envelope Breakdown (Sus scrofa)
Nuclear Envelope Breakdown (Xenopus tropicalis)
Authored
Orlic-Milacic, M (2013-01-23)
Reviewed
Mattaj, IW (2013-01-30)
Gorjánácz, M (2013-01-30)
Created
Orlic-Milacic, M (2013-01-12)
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