NOTCH2 stimulates GZMB transcription

Stable Identifier
R-HSA-2976551
Type
Reaction [omitted]
Species
Homo sapiens
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NOTCH2 coactivator complex together with CREB1 and EP300 stimulates transcription of GZMB (granzyme B), which is important for the cytotoxic function of CD8+ T-cells (Maekawa et al. 2008).

Literature References
PubMed ID Title Journal Year
18724371 Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity

Maekawa, Y, Minato, Y, Ishifune, C, Kurihara, T, Kitamura, A, Kojima, H, Yagita, H, Sakata-Yanagimoto, M, Saito, T, Taniuchi, I, Chiba, S, Sone, S, Yasutomo, K

Nat. Immunol. 2008
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