Reactome | FXYD6 [plasma membrane]

FXYD6 [plasma membrane]

Stable Identifier

R-HSA-2752104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FXYD domain-containing ion transport regulator 6, FXYD6_HUMAN

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        ATP1A:ATP1B:FXYD binds cardiac glycosides (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        FXYDs [plasma membrane] (Homo sapiens)
        
        FXYD6 [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD:cardiac glycosides [plasma membrane] (Homo sapiens)
        
        ATP1A:ATP1B:FXYD [plasma membrane] (Homo sapiens)
        
        FXYDs [plasma membrane] (Homo sapiens)
        
        FXYD6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H0Q3 FXYD6

Gene Names

FXYD6, UNQ521/PRO1056

Chain

signal peptide:1-18, chain:19-95

Reference Genes

BioGPS Gene:53826 FXYD6

COSMIC (genes):FXYD6 FXYD6

CTD Gene:53826 FXYD6

dbSNP Gene:53826 FXYD6

ENSEMBL:ENSG00000137726 FXYD6

ENSEMBL_homo_sapiens_GENE:ENSG00000137726.17 FXYD6

HGNC:4030 FXYD6

KEGG Gene (Homo sapiens):53826 FXYD6

Monarch:53826 FXYD6

NCBI Gene:53826 FXYD6

OMIM:606683 FXYD6

UCSC:Q9H0Q3 FXYD6

Reference Transcript

Other Identifiers

11747154_a_at

11747155_s_at

11747156_x_at

11747319_a_at

11754141_x_at

217897_PM_at

217897_at

3393484

3393485

3393486

3393487

3393490

3393491

3393492

3393493

3393495

3393496

3393506

3393516

3393527

3393528

3393529

53826

65867_at

7951977

A_23_P150394

GE61454

GO:0003674

GO:0005515

GO:0005886

GO:0006811

GO:0008150

GO:0016020

GO:0017080

GO:0034220

GO:0042734

GO:0043269

GO:0045211

GO:0055085

GO:0098772

GO:0098978

GO:0099106

HMNXSV003032911

ILMN_1768812

PH_hs_0024842

TC11003370.hg

g11612654_3p_at

p33758

Participates

as a member of

FXYDs [plasma membrane] (Homo sapiens)

Inferred To

FXYD6 [plasma membrane] (Bos taurus)

FXYD6 [plasma membrane] (Canis familiaris)

FXYD6 [plasma membrane] (Gallus gallus)

FXYD6 [plasma membrane] (Sus scrofa)

Fxyd6 [plasma membrane] (Mus musculus)

Fxyd6 [plasma membrane] (Rattus norvegicus)

fxyd6 [plasma membrane] (Xenopus tropicalis)

zgc:63716 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001158304.1, NP_001158308.1, NP_001158309.1, NP_001158303.1, NP_071286.1

OpenTargets

ENSG00000137726

GeneCards

Q9H0Q3

HPA

ENSG00000137726-FXYD6

Ensembl

ENSP00000463158, ENST00000527717, ENST00000524656, ENSP00000431446, ENST00000260282, ENST00000530956, ENSP00000260282, ENSP00000433312, ENSP00000431427, ENSG00000137726, ENST00000526014, ENST00000539526, ENSP00000442756

PRO

Q9H0Q3

Pharos - Targets

Q9H0Q3

PDB

8D3W, 8D3V, 8D3Y, 8D3U, 8D3X

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.718	6
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q8IUN9 CLEC10A	1	CLEC10A [plasma membrane] (R-HSA-1472863)	0.556	3
UniProt:Q9NXB9 ELOVL2	1	ELOVL2 [endoplasmic reticulum membrane] (R-HSA-548677)	0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q3SXY8 ARL13B	8	PolyUb-Misfolded ARL13B [lysosomal lumen] (R-HSA-9660004) PolyUb-Misfolded ARL13B [cytosol] (R-HSA-9641129) Ub-Misfolded ARL13B [cytosol] (R-HSA-9641119) Misfolded ARL13B [cytosol] (R-HSA-9640110) Misfolded ARL13B [cilium] (R-HSA-9640116) ARL13B [cilium] (R-HSA-5618181) PolyUb-Misfolded ARL13B [late endosome lumen] (R-HSA-9659986) ARL13B [plasma membrane] (R-HSA-9716787)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q9UBD6 RHCG	1	RHCG [plasma membrane] (R-HSA-444397)	0.556	3
UniProt:P25090 FPR2	4	FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [tertiary granule membrane] (R-HSA-6803296) FPR2 [plasma membrane] (R-HSA-416408)	0.556	3
UniProt:Q3KNW5 SLC10A6	1	SLC10A6 [plasma membrane] (R-HSA-433091)	0.556	3
UniProt:Q14973 SLC10A1	1	SLC10A1 [plasma membrane] (R-HSA-194116)	0.556	3

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