Reactome | ABC transporters in lipid homeostasis

ABC transporters in lipid homeostasis

Stable Identifier

R-HSA-1369062

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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A defined subset of the ABC transporter superfamily, the ABCA transporters, are highly expressed in monocytes and macrophages and are regulated by cholesterol flux which may indicate their role in in chronic inflammatory diseases (Schmitz and Kaminski 2001, Schmitz et al. 2000). Some D and G members of the ABC transporter family are also important in lipid transport (Voloshyna & Reiss 2011, Morita & Imanaka 2012, Morita et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21039332	ABC subfamily D proteins and very long chain fatty acid metabolism as novel targets in adrenoleukodystrophy Shimozawa, N, Suzuki, Y, Imanaka, T, Kashiwayama, Y, Morita, M	Curr Drug Targets	2011
11048892	ABC transporters in cellular lipid trafficking Schmitz, G, Orsó, E, Kaminski, WE	Curr Opin Lipidol	2000
21352852	The ABC transporters in lipid flux and atherosclerosis Reiss, AB, Voloshyna, I	Prog. Lipid Res.	2011
22366764	Peroxisomal ABC transporters: structure, function and role in disease Morita, M, Imanaka, T	Biochim. Biophys. Acta	2012
11229879	ABC transporters and cholesterol metabolism Schmitz, G, Kaminski, WE	Front Biosci	2001