Reactome | NPC1L1 binds ezetimibe

NPC1L1 binds ezetimibe

Stable Identifier

R-HSA-265456

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

NPC1L1 inactivation by ezetimibe, NPC1L1 + ezetimibe => NPC1L1:ezetimibe complex

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human NPC1L1, associated with the plasma membrane, binds ezetimibe and becomes incapable of mediating cholesterol uptake. The molecular mechanisms of cholesterol transport and ezetimibe inhibition, however, remain unclear (Garcia-Calvo et al. 2005; Weinglass et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18187582	Madin-Darby canine kidney II cells: a pharmacologically validated system for NPC1L1-mediated cholesterol uptake Beers, L, Nketiah, EO, Thomas, A, Schmalhofer, W, Williams, B, Köhler, MG, Bleasby, K, Leone, J, Hafey, M, Smith, L, Kaczorowski, GJ, Garcia, ML, Braun, MP, Tang, YS, Ujjainwalla, F, Liu, J, McCann, ME, Weinglass, AB	Mol Pharmacol	2008
15928087	The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1) Lisnock, J, Garcia-Calvo, M, Shevell, DE, Iyer, SP, Chapman, KT, Smith, MM, Altmann, SW, Detmers, PA, Ogawa, A, Thornberry, NA, Dean, DC, Bull, HG, Crona, JH, Davis HR, Jr, O'Neill, KA, Graziano, MP, Makarewicz, AM, Braun, MP, Hughes, M, Tang, YS, Hawes, BE, Ujjainwalla, F, Macintyre, DE, Burnett, DA	Proc Natl Acad Sci U S A	2005