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NPC1L1-1 [plasma membrane]
Stable Identifier
R-HSA-265453
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Niemann-Pick C1-like 1 protein, NPC1L1 isoform 1
Icon
Locations in the PathwayBrowser
Expand all
Digestion and absorption (Homo sapiens)
Intestinal absorption (Homo sapiens)
Intestinal lipid absorption (Homo sapiens)
NPC1L1 binds ezetimibe (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1:ezetimibe [plasma membrane] (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1-mediated cholesterol uptake (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1:ezetimibe [plasma membrane] (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1-mediated phytosterol uptake (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHC9-2 NPC1L1
Gene Names
NPC1L1
Other Identifiers
11730055_a_at
11741469_a_at
11752218_a_at
17057305
220106_PM_at
220106_at
224305_PM_s_at
224305_s_at
224306_PM_at
224306_at
29881
3048713
3048714
3048715
3048716
3048717
3048718
3048719
3048720
3048721
3048722
3048723
3048725
3048726
3048727
3048728
3048729
3048730
3048731
3048732
3048733
3048734
3048735
3048736
3048737
3048738
3048739
3048740
3048741
54375_at
8139367
A_23_P20075
A_24_P324712
GE58533
GO:0005215
GO:0005319
GO:0005515
GO:0005886
GO:0006629
GO:0006695
GO:0006766
GO:0008092
GO:0008203
GO:0008289
GO:0008431
GO:0009410
GO:0014850
GO:0015485
GO:0016020
GO:0016324
GO:0022600
GO:0030299
GO:0030301
GO:0030659
GO:0031267
GO:0031410
GO:0031489
GO:0031526
GO:0042157
GO:0042360
GO:0042632
GO:0042803
GO:0043226
GO:0051180
GO:0070508
GO:0071501
GO:1901363
HMNXSV003008213
ILMN_1787556
PH_hs_0026728
TC07001342.hg
g6643037_3p_a_at
g6643037_3p_at
g6643037_3p_x_at
g7019468_3p_at
Participates
as a component of
NPC1L1:ezetimibe [plasma membrane] (Homo sapiens)
as an input of
NPC1L1 binds ezetimibe (Homo sapiens)
Inferred To
Npc1l1 [plasma membrane]
(Mus musculus)
Npc1l1 [plasma membrane]
(Rattus norvegicus)
NCR1 [plasma membrane]
(Saccharomyces cerevisiae)
ncr-2 [plasma membrane]
(Caenorhabditis elegans)
Npc1a [plasma membrane]
(Drosophila melanogaster)
ncr-1 [plasma membrane]
(Caenorhabditis elegans)
NPC1L1 [plasma membrane]
(Canis familiaris)
NPC1L1 [plasma membrane]
(Sus scrofa)
NPC1L1-1 [plasma membrane]
(Bos taurus)
NPC1L1-1 [plasma membrane]
(Dictyostelium discoideum)
Npc1b [plasma membrane]
(Drosophila melanogaster)
npcA [plasma membrane]
(Dictyostelium discoideum)
Homologues of NPC1L1-1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of NPC1L1-1 [plasma membrane]
(Dictyostelium discoideum)
Homologues of NPC1L1-1 [plasma membrane]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
2629
ENSEMBL
ENSP00000404670
,
ENST00000423141
,
ENST00000289547
,
ENSP00000289547
OpenTargets
ENSG00000015520
ZINC - Substances
NPCL1_HUMAN
ZINC - Biogenic
NPCL1_HUMAN
ZINC target
Q9UHC9
PRO
Q9UHC9
GlyGen
Q9UHC9
PDB
7N4U
,
3QNT
,
7DFZ
,
7DF8
,
7DFW
,
7N4X
,
7N4V
ZINC - Metabolites
NPCL1_HUMAN
HPA
ENSG00000015520-NPC1L1
Pharos - Targets
Q9UHC9
ZINC - Predictions - Purchasable
NPCL1_HUMAN
HMDB Protein
HMDBP02773
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