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NPC1L1-1 [plasma membrane]
Stable Identifier
R-HSA-265453
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Niemann-Pick C1-like 1 protein, NPC1L1 isoform 1
Icon
Locations in the PathwayBrowser
Expand all
Digestion and absorption (Homo sapiens)
Intestinal absorption (Homo sapiens)
Intestinal lipid absorption (Homo sapiens)
NPC1L1 binds ezetimibe (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1:ezetimibe [plasma membrane] (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1-mediated cholesterol uptake (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1:ezetimibe [plasma membrane] (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
NPC1L1-mediated phytosterol uptake (Homo sapiens)
NPC1L1-1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UHC9-2 NPC1L1
Gene Names
NPC1L1
Other Identifiers
0002340524
11730055_a_at
11741469_a_at
11752218_a_at
17057305
220106_PM_at
220106_at
224305_PM_s_at
224305_s_at
224306_PM_at
224306_at
29881
3048713
3048714
3048715
3048716
3048717
3048718
3048719
3048720
3048721
3048722
3048723
3048725
3048726
3048727
3048728
3048729
3048730
3048731
3048732
3048733
3048734
3048735
3048736
3048737
3048738
3048739
3048740
3048741
54375_at
8139367
A_23_P20075
A_24_P324712
GE58533
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005886
GO:0006629
GO:0006695
GO:0006810
GO:0006950
GO:0008092
GO:0008150
GO:0008202
GO:0008203
GO:0009058
GO:0016020
GO:0016021
GO:0016324
GO:0019899
GO:0030299
GO:0030301
GO:0030659
GO:0031267
GO:0031410
GO:0031489
GO:0042157
GO:0043226
GO:0044214
GO:0044281
GO:0071501
HMNXSV003008213
ILMN_1787556
PH_hs_0026728
TC07001342.hg
g6643037_3p_a_at
g6643037_3p_at
g6643037_3p_x_at
g7019468_3p_at
Participates
as a component of
NPC1L1:ezetimibe [plasma membrane] (Homo sapiens)
as an input of
NPC1L1 binds ezetimibe (Homo sapiens)
Inferred To
Npc1l1 [plasma membrane]
(Mus musculus)
Npc1l1 [plasma membrane]
(Rattus norvegicus)
NCR1 [plasma membrane]
(Saccharomyces cerevisiae)
npc1l1 [plasma membrane]
(Danio rerio)
npc1l1 [plasma membrane]
(Xenopus tropicalis)
ncr-2 [plasma membrane]
(Caenorhabditis elegans)
Npc1a [plasma membrane]
(Drosophila melanogaster)
ncr-1 [plasma membrane]
(Caenorhabditis elegans)
NPC1L1 [plasma membrane]
(Bos taurus)
NPC1L1 [plasma membrane]
(Sus scrofa)
NPC1L1-1 [plasma membrane]
(Dictyostelium discoideum)
Npc1b [plasma membrane]
(Drosophila melanogaster)
npcA [plasma membrane]
(Dictyostelium discoideum)
Homologues of NPC1L1-1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of NPC1L1-1 [plasma membrane]
(Dictyostelium discoideum)
Homologues of NPC1L1-1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_037521.2
,
NP_001095118.1
,
NP_001287896.1
Guide to Pharmacology - Targets
2629
OpenTargets
ENSG00000015520
ZINC - Substances
NPCL1_HUMAN
ZINC target
Q9UHC9
ZINC - Biogenic
NPCL1_HUMAN
PRO
Q9UHC9
PDB
7N4X
,
7N4U
,
3QNT
,
7N4V
ZINC - Metabolites
NPCL1_HUMAN
GeneCards
Q9UHC9
HPA
ENSG00000015520-NPC1L1
Ensembl
ENST00000423141
,
ENSP00000404670
,
ENSG00000015520
,
ENSP00000289547
,
ENST00000289547
Pharos - Targets
Q9UHC9
Orphanet
23129
ZINC - Predictions - Purchasable
NPCL1_HUMAN
HMDB Protein
HMDBP02773
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