Reactome | Intestinal lipid absorption

Intestinal lipid absorption

Stable Identifier

R-HSA-8963678

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Niemann-Pick C1 Like 1 (NPC1L1) protein in enterocytes is critical for intestinal cholesterol and phytosterol absorption, and is the target of the drug ezetimibe (Davis et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
15173162	Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis Iyer, SP, Altmann, SW, Detmers, PA, Lam, MH, Maguire, M, Yao, X, Tetzloff, G, Davis, HR, Lund, EG, Liu, J, Graziano, MP, Hoos, LM, Zhu, LJ	J. Biol. Chem.	2004