RDH8 reduces atRAL to atROL

Stable Identifier
R-HSA-2464803
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, photoreceptor outer segment membrane
ReviewStatus
5/5
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RDH8 reduces atRAL to atROL
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The reversible, NADP(H)-dependent reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL) occurs in both rod and cone photoreceptor cells where multiple retinol dehydrogenases (RHDs) are located. RHDs belong to the short-chain dehydrogenase/reductase (SDR) superfamily. RDH8 (located in photoreceptor outer segments) is partially responsible, together with other RDHs, for mediating this reaction. The activity for human RDH8 is inferred from a bovine experiment (Rattner et al. 2000).
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Output
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as an event of
Catalyst Activity

all-trans-retinol dehydrogenase (NADP+) activity of RDH8-like proteins [photoreceptor outer segment membrane]

Physical Entity
RDH8-like proteins [photoreceptor outer segment membrane] (Homo sapiens)
Activity
all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)
Inferred From
Rdh8 reduces atRAL to atROL (Bos taurus)
Cross References
RHEA
Authored
Jassal, B  (2012-09-03)
Reviewed
Blaner, WS  (2013-01-31)
Created
Jassal, B  (2012-09-03)
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