Reactome | Rdh8 reduces atRAL to atROL

Rdh8 reduces atRAL to atROL

Stable Identifier

R-BTA-2464776

Type

Reaction [transition]

Species

Bos taurus

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

General

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The reversible, NADP(H)-dependent reduction of all-trans-retinal (atRAL) to all-trans-retinol (atROL) occurs in both rod and cone photoreceptor cells where multiple retinol dehydrogenases (RHDs) are located. RHDs belong to the short-chain dehydrogenase/reductase (SDR) superfamily. RDH8 (located in photoreceptor outer segments) is partially responsible, together with other RDHs, for mediating this reaction. The activity for human RDH8 is inferred from a bovine experiment (Rattner et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10753906	Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. Nathans, J, Rattner, A, Smallwood, PM	J Biol Chem	2000

Participants

Input

Output

Catalyst Activity

all-trans-retinol dehydrogenase (NADP+) activity of Rdh8 [photoreceptor outer segment membrane]

Physical Entity

Rdh8 [photoreceptor outer segment membrane] (Bos taurus)

Activity

all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)

Orthologous Events

RDH8 reduces atRAL to atROL (Homo sapiens)

Created

Jassal, B (2012-09-03)

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