p-T,4S-IRF3 is dimerized

Stable Identifier
R-HSA-2395992
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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IRF3 phosphorylation promotes IRF3 dimerization and nuclear translocation, which results in the production of type I interferons (IFNs).

Literature References
PubMed ID Title Journal Year
17526488 Interferon regulatory factor 3 is regulated by a dual phosphorylation-dependent switch

Panne, D, McWhirter, SM, Maniatis, T, Harrison, SC

J Biol Chem 2007
17483521 Mechanisms of activation of interferon regulator factor 3: the role of C-terminal domain phosphorylation in IRF-3 dimerization and DNA binding

Dragan, AI, Hargreaves, VV, Makeyeva, EN, Privalov, PL

Nucleic Acids Res. 2007
11035028 Identification of distinct signaling pathways leading to the phosphorylation of interferon regulatory factor 3

Servant, MJ, ten Oever, B, LePage, C, Conti, L, Gessani, S, Julkunen, I, Lin, R, Hiscott, J

J. Biol. Chem. 2001
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