Interferon regulatory factors (IRF) IRF-3 and IRF-7 are the major modulators of IFN gene expression in response to pathogenic molecules. The relative contribution of IRF3 and IRF7 depends on the signaling pathway that is activated. Type I IFN production in cytosolic DNA-sensing pathway is mediated predominantly by IRF3 and partially by IRF7, since DNA-stimulated IFN-beta and IFN-alpha4 mRNA induction was strongly inhibited in IRF3-deficient mouse embryonic fibroblasts (MEFs), while remained normal (IFN-beta) or reduced (IFN-alpha4) in IRF7-deficient MEFs (Takaoke A et al 2007). IRF3 activation in response to B-DNA stimulation occurs via its co-recruitment with serine/threonine kinase TANK-binding kinase 1 (TBK1) or inducible IkB kinase (IKKi/IKKepsilon) to the C-terminal region of DAI.
Lu, Y, Tamura, T, Choi, MK, Ban, T, Yanai, H, Wang, Z, Takaoka, A, Nishikura, K, Taniguchi, T, Negishi, H
Medzhitov, R, Stetson, DB
Lu, Y, Choi, MK, Ohba, Y, Ban, T, Miyagishi, M, Yanai, H, Honda, K, Wang, Z, Takaoka, A, Taniguchi, T, Kodama, T, Negishi, H
Früh, K, Sali, T, Alvarado, D, Rothenburg, S, DeFilippis, VR
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