IRF3 mediated activation of type 1 IFN

Stable Identifier
Homo sapiens
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Interferon regulatory factors (IRF) IRF-3 and IRF-7 are the major modulators of IFN gene expression in response to pathogenic molecules. The relative contribution of IRF3 and IRF7 depends on the signaling pathway that is activated. Type I IFN production in cytosolic DNA-sensing pathway is mediated predominantly by IRF3 and partially by IRF7, since DNA-stimulated IFN-beta and IFN-alpha4 mRNA induction was strongly inhibited in IRF3-deficient mouse embryonic fibroblasts (MEFs), while remained normal (IFN-beta) or reduced (IFN-alpha4) in IRF7-deficient MEFs (Takaoke A et al 2007). IRF3 activation in response to B-DNA stimulation occurs via its co-recruitment with serine/threonine kinase TANK-binding kinase 1 (TBK1) or inducible IkB kinase (IKKi/IKKepsilon) to the C-terminal region of DAI.

Literature References
PubMed ID Title Journal Year
18375758 Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

Lu, Y, Tamura, T, Choi, MK, Ban, T, Yanai, H, Wang, Z, Takaoka, A, Nishikura, K, Taniguchi, T, Negishi, H

Proc Natl Acad Sci U S A 2008
16413926 Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

Medzhitov, R, Stetson, DB

Immunity 2006
17618271 DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

Lu, Y, Choi, MK, Ohba, Y, Ban, T, Miyagishi, M, Yanai, H, Honda, K, Wang, Z, Takaoka, A, Taniguchi, T, Kodama, T, Negishi, H

Nature 2007
19846511 Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1

Früh, K, Sali, T, Alvarado, D, Rothenburg, S, DeFilippis, VR

J Virol 2010
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