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NUDT15 [cytosol]
Stable Identifier
R-HSA-2394014
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
8-oxo-dGTP diphosphatase NUDT15, MTH2
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
NUDT15 dimer dephosphorylates 6TdGTP to 6TdGMP (Homo sapiens)
NUDT15 dimer [cytosol] (Homo sapiens)
NUDT15 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Nucleotide catabolism (Homo sapiens)
Purine catabolism (Homo sapiens)
Phosphate bond hydrolysis by NUDT proteins (Homo sapiens)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP (Homo sapiens)
NUDT15 [cytosol] (Homo sapiens)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP (Homo sapiens)
NUDT15 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NV35 NUDT15
Gene Names
NUDT15, MTH2
Chain
chain:1-164
Reference Genes
BioGPS Gene:55270 NUDT15
COSMIC (genes):NUDT15 NUDT15
CTD Gene:55270 NUDT15
dbSNP Gene:55270 NUDT15
ENSEMBL:ENSG00000136159 NUDT15
HGNC:23063 NUDT15
KEGG:hsa:55270 NUDT15
Monarch:55270 NUDT15
NCBI Gene:55270 NUDT15
OMIM:615792 NUDT15
UCSC:Q9NV35 NUDT15
Reference Transcript
RefSeq:NM_018283.4 NUDT15
RefSeq:NM_001304745.1 NUDT15
Other Identifiers
11758564_s_at
16774669
219347_PM_at
219347_at
3488945
3488946
3488949
3488953
3488954
3488955
3488956
3488957
3488958
3752686
55270
59994_at
64009_at
7968999
A_24_P244699
GE55924
GO:0000278
GO:0000302
GO:0005515
GO:0005829
GO:0006195
GO:0006203
GO:0006950
GO:0008413
GO:0009217
GO:0016787
GO:0035539
GO:0042178
GO:0042262
GO:0044715
GO:0046872
GO:0047429
GO:0055086
GO:0061136
GO:1901135
GO:1901292
HMNXSV003046646
ILMN_1751403
ILMN_2172202
PH_hs_0008537
TC13000187.hg
g8922791_3p_at
Participates
as a component of
NUDT15 dimer [cytosol] (Homo sapiens)
Inferred To
Nudt15 [cytosol]
(Mus musculus)
nudt15 [cytosol]
(Danio rerio)
nudt15 [cytosol]
(Xenopus tropicalis)
NUDT15 [cytosol]
(Bos taurus)
NUDT15 [cytosol]
(Canis familiaris)
NUDT15 [cytosol]
(Gallus gallus)
NUDT15 [cytosol]
(Rattus norvegicus)
NUDT15 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_060753.1
,
NP_001291674.1
ENSEMBL
ENSP00000258662
,
ENSG00000136159
,
ENST00000258662
OpenTargets
ENSG00000136159
IntEnz
3.6.1.9
GeneCards
NUDT15
HPA
ENSG00000136159-NUDT15
PRO
Q9NV35
Pharos - Targets
Q9NV35
GlyGen
Q9NV35
HMDB Protein
HMDBP08777
PDB
7B66
,
7B65
,
7B7V
,
6T5J
,
7B67
,
7R0D
,
5LPG
,
7NR6
,
7B64
,
7AOM
,
5BON
,
7B63
,
7AOP
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60520 GABARAPL2
3
GABARAPL2 [cytosol]
(R-HSA-5671758)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
0.556
3
UniProt:Q6UWW0 LCN15
1
LCN15 [extracellular region]
(R-HSA-5216200)
0.527
2
UniProt:Q9BRK4 LZTS2
0.527
2
UniProt:Q5T0J3 CA220
0.527
2
UniProt:A2RUU4 COLL1
0.527
2
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