Reactome | 5S-HpETE is reduced to 5S-HETE by GPX1/2/4

5S-HpETE is reduced to 5S-HETE by GPX1/2/4

Stable Identifier

R-HSA-2161946

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

ReviewStatus

5/5

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5S-HpETE is reduced to 5S-HETE by GPX1/2/4

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Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) reduce 5-hydroperoxyeicosatetraenoic acid (5-HpETE) to 5-hydroxyeicosatetraenoic acid (5-HETE) in the presence of glutathione (GSH). This reaction is inferred from the event in rabbit involving the protein GPX1 (Chiba et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
11115402	Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism Sutherland, M, Shankaranarayanan, P, Schewe, T, Nigam, S	Biochem J	2001
10549853	Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages Chiba, N, Imai, H, Narashima, K, Arai, M, Oshima, G, Kunimoto, M, Nakagawa, Y	Biol Pharm Bull	1999
6816802	Role of glutathione peroxidase and hexose monophosphate shunt in the platelet lipoxygenase pathway Bryant, RW, Simon, TC, Bailey, JM	J Biol Chem	1982
8428933	Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI Chu, FF, Doroshow, JH, Esworthy, RS	J Biol Chem	1993

Participants

Input

5S-HpETE [cytosol]
x 2 GSH [cytosol]

Output

Participates

as an event of

Synthesis of 5-eicosatetraenoic acids (Homo sapiens)

Catalyst Activity

glutathione peroxidase activity of GPX1/2/4 [cytosol]

Physical Entity

GPX1/2/4 [cytosol] (Homo sapiens)

Activity

glutathione peroxidase activity (GO:0004602)

Inferred From

5S-HpETE is reduced to 5S-HETE by GPX1 (Oryctolagus cuniculus)

Cross References

RHEA

48621, 48621

Authored

Williams, MG (2012-02-24)

Reviewed

Rush, MG (2012-11-10)

Created

Williams, MG (2012-03-14)

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