5S-HpETE is reduced to 5S-HETE by GPX1

Stable Identifier
R-OCU-2161896
Type
Reaction [transition]
Species
Oryctolagus cuniculus
Compartment
cytosol
Synonyms
(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione => (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
ReviewStatus
5/5
General
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5S-HpETE is reduced to 5S-HETE by GPX1
The cytosol of rabbit lung alveolar macrophages contains a high amount of glutathione peroxidase 1 (GPX1), which reduces 5-hydroperoxyeicosatetraenoic acid (5-HPETE) to 5-hydroxyeicosatetraenoic acid (5-HETE) in the presence of glutathione (GSH) (Chiba et al. 1999). Current literature suggests that 5-HETE itself does not appear to play a significant role in biological signalling. However, it can be further oxidised by a 5-hydroxy-eicosatetraenoic acid dehydrogenase (5-HEDH) to form the bioactive 5-oxo-eicosatetraenoic acid (5-oxoETE) aka 5-KETE.
Literature References
PubMed ID Title Journal Year
10549853 Cellular glutathione peroxidase as a predominant scavenger of hydroperoxyeicosatetraenoic acids in rabbit alveolar macrophages

Chiba, N, Imai, H, Narashima, K, Arai, M, Oshima, G, Kunimoto, M, Nakagawa, Y

Biol Pharm Bull 1999
Participants
Input
Output
Catalyst Activity

glutathione peroxidase activity of GPX1 tetramer [cytosol]

Physical Entity
GPX1 tetramer [cytosol] (Oryctolagus cuniculus)
Activity
glutathione peroxidase activity (GO:0004602)
Orthologous Events
5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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