Reactome | LTBP4 [extracellular region]

LTBP4 [extracellular region]

Stable Identifier

R-HSA-2161309

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Latent-transforming growth factor beta-binding protein 4, LTBP4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q8N2S1 LTBP4

Gene Names

LTBP4

Chain

signal peptide:1-27, chain:28-1624

Reference Genes

BioGPS Gene:8425 LTBP4

COSMIC - genes:LTBP4 LTBP4

CTD Gene:8425 LTBP4

dbSNP Gene:8425 LTBP4

ENSEMBL:ENSG00000090006 LTBP4

HGNC:6717 LTBP4

KEGG:hsa:8425 LTBP4

Monarch:8425 LTBP4

NCBI Gene:8425 LTBP4

OMIM:604710 LTBP4

UCSC:Q8N2S1 LTBP4

Reference Transcript

Participates

as a member of

LTBPs [extracellular region] (Homo sapiens)

as a component of

LTBP4:TGFB1:LAP1 [extracellular region] (Homo sapiens)

as an input of

LTBP4 binds TGF-Beta-1 (Homo sapiens)

Inferred To

LTBP4 [extracellular region] (Bos taurus)

LTBP4 [extracellular region] (Canis familiaris)

LTBP4 [extracellular region] (Dictyostelium discoideum)

LTBP4 [extracellular region] (Gallus gallus)

LTBP4 [extracellular region] (Sus scrofa)

Homologues of LTBP4 [extracellular region] (Dictyostelium discoideum)

nid-1 [extracellular region] (Caenorhabditis elegans)

Ltbp4 [extracellular region] (Mus musculus)

Ltbp4 [extracellular region] (Rattus norvegicus)

Cross References

RefSeq

NP_001036009.1, NP_001036010.1, NP_003564.2

ENSEMBL

ENSP00000380031, ENST00000308370, ENST00000396819, ENSP00000311905, ENSG00000090006

OpenTargets

ENSG00000090006

GeneCards

LTBP4

HPA

ENSG00000090006-LTBP4

PRO

Q8N2S1

Pharos - Targets

Q8N2S1

GlyGen

Q8N2S1

Orphanet

LTBP4

HMDB Protein

HMDBP14554

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8WTR8 NET5			0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:Q04721 NOTCH2	18	NOTCH2(1582-1665) [extracellular region] (R-HSA-157652) NOTCH2(1666-1696) [plasma membrane] (R-HSA-157628) NEXT2 [plasma membrane] (R-HSA-157225) NICD2 [cytosol] (R-HSA-157642) NICD2 [nucleoplasm] (R-HSA-157942) Glc,GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911428) Glc,Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911417) Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH2 [Golgi membrane] (R-HSA-1911505) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [Golgi membrane] (R-HSA-1983676) NOTCH2(1582-2471) [Golgi membrane] (R-HSA-157017) 18xFucT-16xGlcS-FucS-NOTCH2(26-1581) [extracellular region] (R-HSA-1983678) NOTCH2(1582-2471) [plasma membrane] (R-HSA-157228) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [Golgi membrane] (R-HSA-1472874) 18xFucT-16xGlcS-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467379) 18xFucT-FucS-NOTCH2(26-2471) [endoplasmic reticulum membrane] (R-HSA-1467363) Pre-NOTCH2 [endoplasmic reticulum membrane] (R-HSA-157025) FRINGE-modified NOTCH2 extracellular fragment (NECD2) [Golgi membrane] (R-HSA-1911520) FRINGE-modified NOTCH2 Extracellular Fragment (NECD2) [plasma membrane] (R-HSA-1911518)	0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	2
UniProt:Q16587 ZNF74	1	ZNF74 [nucleoplasm] (R-HSA-2586601)	0.527	2
UniProt:Q9UBX5 FBLN5	1	FBLN5 [extracellular region] (R-HSA-2161278)	0.527	2
UniProt:O15265 ATXN7	2	ATXN7 [cytosol] (R-HSA-201591) ATXN7 [nucleoplasm] (R-HSA-8869458)	0.508	2
UniProt:O00555 CACNA1A	1	CACNA1A [plasma membrane] (R-HSA-210490)	0.508	2

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