Reactome | CGN [cell junction]

CGN [cell junction]

Stable Identifier

R-HSA-2134478

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cell junction

Synonyms

Cingulin

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
      - Disassembly of tight junctions (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
      - SMURF1 binds phosphorylated PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
      - SMURF1 ubiquitinates RHOA (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
      - TGFBR1 is recruited to tight junctions by PARD6A (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
      - TGFBR2 is recruited to tight junctions after TGF-beta stimulation (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
      - TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:TGFBR1:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        CGN [cell junction] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9P2M7 CGN

Gene Names

CGN, KIAA1319

Chain

chain:1-1203

Reference Genes

BioGPS Gene:57530 CGN

COSMIC (genes):CGN CGN

CTD Gene:57530 CGN

dbSNP Gene:57530 CGN

ENSEMBL:ENSG00000143375 CGN

ENSEMBL_homo_sapiens_GENE:ENSG00000143375.15 CGN

HGNC:17429 CGN

KEGG Gene (Homo sapiens):57530 CGN

Monarch:57530 CGN

NCBI Gene:57530 CGN

OMIM:609473 CGN

UCSC:Q9P2M7 CGN

Reference Transcript

Other Identifiers

11740114_a_at

11740115_a_at

11755174_a_at

16670866

223232_PM_s_at

223232_s_at

223233_PM_s_at

223233_s_at

2358955

2358957

2358959

2358960

2358961

2358964

2358966

2358967

2358968

2358969

2358970

2358971

2358972

2358974

2358975

2358977

2358978

2358980

2358982

2358985

2358987

2358989

2358991

2358992

57530

63775_at

7905406

89967_at

A_23_P149390

A_24_P45728

A_33_P3329974

GE53901

GO:0000226

GO:0003779

GO:0005515

GO:0005856

GO:0005886

GO:0005923

GO:0007010

GO:0008017

GO:0008092

GO:0008150

GO:0016459

GO:0030054

GO:0043226

GO:0045296

GO:0070161

HMNXSV003036818

HMNXSV003042541

Hs.18376.0.S1_3p_a_at

ILMN_1746801

TC01001211.hg

g8308175_3p_a_at

Participates

as a component of

Inferred To

cgn [cell junction] (Danio rerio)

cgn [cell junction] (Xenopus tropicalis)

Cgn [cell junction] (Mus musculus)

Cgn [cell junction] (Rattus norvegicus)

Ghost homologue of CGN [cell junction] (Caenorhabditis elegans)

Ghost homologue of CGN [cell junction] (Drosophila melanogaster)

Ghost homologue of CGN [cell junction] (Gallus gallus)

CGN [cell junction] (Bos taurus)

CGN [cell junction] (Canis familiaris)

CGN [cell junction] (Sus scrofa)

Cross References

RefSeq

NP_065821.1, XP_005245422.1

OpenTargets

ENSG00000143375

HPA

ENSG00000143375-CGN

GeneCards

Q9P2M7

Ensembl

ENSP00000271636, ENSG00000143375, ENST00000271636

PRO

Q9P2M7

Pharos - Targets

Q9P2M7

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.792	6
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.706	5
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.65	4
UniProt:Q07157 TJP1	5	TJP1 [cell junction] (R-HSA-8936023) TJP1 (?-?) [plasma membrane] (R-HSA-3209844) TJP1 [plasma membrane] (R-HSA-3209845) TJP1 [Golgi-associated vesicle membrane] (R-HSA-3209843) TJP1 [cytosol] (R-HSA-532659)	0.564	2
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	4
UniProt:P62736 ACTA2	1	ACTA2 [cytosol] (R-HSA-445792)	0.527	2