Tight Junction Complex:PARD6A:RHOA [cell junction]

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
In this complex, PARD3:PARD6A:PRKCZ is bound to JAM-A. JAM-A also binds CGN (cingulin), and CGN binds ARHGEF18, which binds RHOA. Not all components of the tight junction structure are shown.
Literature References
PubMed ID Title Journal Year
10877843 Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin

Orsenigo, F, Citi, S, Dejana, E, Cordenonsi, M, Martinez-Estrada, OM, Bazzoni, G

J Biol Chem 2000
21258369 Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

Terry, SJ, Elbediwy, A, Vitiello, E, Leefa Chong San, IV, Matter, K, Balda, MS, Zihni, C

Nat Cell Biol 2011
12953056 The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity

Imhof, BA, Meyer zu Brickwedde, MK, Butz, S, Aurrand-Lions, M, Zander, K, Kuhn, A, Ebnet, K, Kiefer, F, Vestweber, D, Suzuki, A

J Cell Sci 2003
11447115 The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

Ohno, S, Meyer zu Brickwedde, MK, Ebnet, K, Vestweber, D, Hirose, T, Horikoshi, Y, Suzuki, A

EMBO J 2001
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