Tight Junction Complex:PARD6A:RHOA

Stable Identifier
R-HSA-2134514
Type
Complex
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In this complex, PARD3:PARD6A:PRKCZ is bound to JAM-A. JAM-A also binds CGN (cingulin), and CGN binds ARHGEF18, which binds RHOA. Not all components of the tight junction structure are shown.

Literature References
PubMed ID Title Journal Year
21258369 Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis

Terry, SJ, Zihni, C, Elbediwy, A, Vitiello, E, Leefa Chong San, IV, Balda, MS, Matter, K

Nat Cell Biol 2011
10877843 Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin

Bazzoni, G, Martinez-Estrada, OM, Orsenigo, F, Cordenonsi, M, Citi, S, Dejana, E

J Biol Chem 2000
12953056 The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity

Ebnet, K, Aurrand-Lions, M, Kuhn, A, Kiefer, F, Butz, S, Zander, K, Meyer zu Brickwedde, MK, Suzuki, A, Imhof, BA, Vestweber, D

J Cell Sci 2003
11447115 The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)

Ebnet, K, Suzuki, A, Horikoshi, Y, Hirose, T, Meyer zu Brickwedde, MK, Ohno, S, Vestweber, D

EMBO J 2001
Participants
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