Reactome | FCER2(1-321) [plasma membrane]

FCER2(1-321) [plasma membrane]

Stable Identifier

R-HSA-2127280

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FCER2, Low affinity immunoglobulin epsilon Fc receptor, CD23A, CD23

Locations in the PathwayBrowser for interactor UniProt:P17544 ATF7

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External Reference Information

External Reference

UniProt:P06734 FCER2

Gene Names

FCER2, CD23A, CLEC4J, FCE2, IGEBF

Chain

chain:1-321, chain:150-321

Reference Genes

BioGPS Gene:2208 FCER2

COSMIC - genes:FCER2 FCER2

CTD Gene:2208 FCER2

dbSNP Gene:2208 FCER2

ENSEMBL:ENSG00000104921 FCER2

HGNC:3612 FCER2

KEGG:hsa:2208 FCER2

Monarch:2208 FCER2

NCBI Gene:2208 FCER2

OMIM:151445 FCER2

UCSC:P06734 FCER2

Reference Transcript

Other Identifiers

11756817_a_at

16867975

206759_PM_at

206759_at

206760_PM_s_at

206760_s_at

2208

34959_at

34960_g_at

3848494

3848495

3848496

3848497

3848498

3848499

3848500

3848501

3848502

3848503

3848505

3848506

3848508

3848509

3848510

3848512

3848513

3848514

3848515

3848516

3848517

3848518

3848519

3848520

3848521

3848522

8033420

A_23_P164773

GE57838

GO:0002020

GO:0002376

GO:0002450

GO:0002925

GO:0005178

GO:0005515

GO:0005576

GO:0005886

GO:0006955

GO:0009897

GO:0010628

GO:0016020

GO:0016192

GO:0019769

GO:0019863

GO:0030246

GO:0038095

GO:0038096

GO:0038187

GO:0042116

GO:0042742

GO:0046872

GO:0070062

GO:0098542

GO:0160006

HMNXSV003043691

ILMN_1662451

M15059_at

PH_hs_0000188

TC19001116.hg

g4503678_3p_a_at

Participates

as a member of

as an output of

NOTCH2 stimulates transcription of FCER2 (CD23A) (Homo sapiens)

Cross References

RefSeq

XP_005272519.1, XP_054176173.1, NP_001993.2, NP_001193948.2, NP_001207429.1

Guide to Pharmacology - Targets

2935

OpenTargets

ENSG00000104921

ENSEMBL

ENST00000346664, ENSP00000471974, ENSP00000264072, ENST00000597921, ENSG00000104921

ZINC - Substances

FCER2_HUMAN

ZINC target

P06734

PRO

P06734

PDB

4KI1, 2H2T, 1T8C, 4G9A, 1T8D, 4GI0, 4GK1, 4GJ0, 4GJX, 5LGK, 4J6Q, 6Y0M, 4J6J, 4J6P, 2H2R, 4G96, 4J6K, 4EZM, 4J6L, 4GKO, 4J6M, 4J6N, 6Y0L

ZINC - Investigational

FCER2_HUMAN

HPA

ENSG00000104921-FCER2

GeneCards

FCER2

Pharos - Targets

P06734

ZINC - Predictions - Purchasable

FCER2_HUMAN

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19022 CDH2	3	p-CDH2 [endoplasmic reticulum lumen] (R-HSA-8956899) CDH2 [endoplasmic reticulum lumen] (R-HSA-8956761) CDH2 [plasma membrane] (R-HSA-191429)	0.602	3
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) p-8Y-FGFR2 K660M [plasma membrane] (R-HSA-2033300) p-8Y-FGFR2 K660E [plasma membrane] (R-HSA-2033298) phosphorylated FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-2071957) p-8Y-FGFR2 W290C [plasma membrane] (R-HSA-2029875) p-8Y-FGFR2 S267P [plasma membrane] (R-HSA-2029879) p-8Y-FGFR2 [plasma membrane] (R-HSA-2029874) p-8Y-FGFR2 N549K [plasma membrane] (R-HSA-2033306)	0.558	2
UniProt:P17544 ATF7			0.556	3

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