NOTCH2 stimulates transcription of FCER2 (CD23A)

Stable Identifier
R-HSA-2127285
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
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NOTCH2 stimulates transcription of FCER2 (CD23A)
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Transient transfection of a human pre-B-cell line REH with a vector encoding recombinant rat NICD2 induces endogenous FCER2 transcription. Overexpression of FCER2 (CD23A) is a hallmark of B-cell chronic lymphocytic leukemia (B-CLL) and correlates with the malfunction of apoptosis, which is thought be an underlying mechanism of B-CLL development. The Epstein-Barr virus protein EBNA2 can also activate FCER2 transcription through RBPJ promoter elements, possibly by mimicking NOTCH2 signaling (Hubmann et al. 2002).
Literature References
PubMed ID Title Journal Year
11986231 Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia

Shehata, M, Berger, R, Schwarzmeier, JD, Duechler, M, Hilgarth, M, Hubmann, R, Dettke, M

Blood 2002
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH2 Coactivator Complex:FCER2 gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH2 Coactivator Complex [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Ilagan, MXG  (2013-04-25)
Boyle, S  (2013-04-25)
Created
Orlic-Milacic, M  (2012-02-15)
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