EGFR interacts with phospholipase C-gamma

Stable Identifier
R-HSA-212718
DOI
10.3180/REACT_12478.1
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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EGFR interacts with phospholipase C-gamma
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Activated epidermal growth factor receptors (EGFR) can stimulate phosphatidylinositol (PI) turnover. Activated EGFR can activate phospholipase C-gamma1 (PLC-gamma1, i.e. PLCG1) which hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). IP3 is instrumental in the release of calcium from intracellular stores and DAG is involved in protein kinase C activation.

Literature References
PubMed ID Title Journal Year
1501243 Epidermal growth factor receptor: elements of intracellular communication

Hernández-Sotomayor, SM, Carpenter, G

J Membr Biol 1992
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Events
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as an event of
Event Information
Go Biological Process
signal transduction (0007165)
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Cross References
BioModels Database
Authored
Jassal, B  (2008-02-13)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2008-02-13)
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