CYP26C1 4-hydroxylates 9cRA

Stable Identifier
R-HSA-211923
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Endogenous retinoic acids (RA) which play a role in gene regulation exist as either cis or trans isomers. While CYP26C1 can also hydroxylate the trans form, it is unique in 4-hydroxylating the 9-cis isomer of RA (9cRA) in vitro (Taimi et al. 2004). However, the importance of 9cRA as an endogenous retinoid outside of the pancreas has not been demonstrated.

Literature References
PubMed ID Title Journal Year
14532297 A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid

Taimi, M, Helvig, C, Wisniewski, J, Ramshaw, H, White, J, Amad, M, Korczak, B, Petkovich, M

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
retinoic acid 4-hydroxylase activity of CYP26C1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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