Release of docked dopamine loaded synaptic vesicle

Stable Identifier
R-HSA-380869
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The trimeric complex formed between V-SNARE (VAMP) and the T-SNAREs (syntaxin and SNAP 25) after priming step is called transSNARE complex because the members of each group lie on the opposide side of the membrane, plasmamembrane side and the vesicular membrane side. Ca2+ influx through the Voltage gated Calcium Channels (VGCC) initaites the process of fusion of the synaptic vesicle in the presynaptic cell. The rise in Ca2+ leads to the activation of Protein Kinase A through rise in cAMP. Synaptotagmin, a Ca2+ sensor proetin also plays a role in the fusion process. Following fusion the members of V and T SNARES lie on the same membrane formin the cis-SNARES. The fusion of release causes the release of the neurotransmitter into the synaptic cleft.

Literature References
PubMed ID Title Journal Year
17478680 How synaptotagmin promotes membrane fusion

Martens, S, Kozlov, MM, McMahon, HT

Science 2007
12519779 Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis

Barclay, JW, Craig, TJ, Fisher, RJ, Ciufo, LF, Evans, GJ, Morgan, A, Burgoyne, RD

J Biol Chem 2003
17891149 Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

Stein, A, Radhakrishnan, A, Riedel, D, Fasshauer, D, Jahn, R

Nat Struct Mol Biol 2007
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Catalyst Activity
Title
SNARE binding activity of Docked dopamine loaded synaptic vesicle [plasma membrane]
Physical Entity
Activity
Orthologous Events
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