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D2,4,4(S)3-DCN [extracellular region]
Stable Identifier
R-HSA-2065093
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
_DCN, Decorin, PGS2_HUMAN, DCN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
CS/DS degradation (Homo sapiens)
DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)
DSPGs [extracellular region] (Homo sapiens)
D2,4,4(S)3-PGs [extracellular region] (Homo sapiens)
D2,4,4(S)3-DCN [extracellular region] (Homo sapiens)
Dermatan sulfate biosynthesis (Homo sapiens)
DSPGs are secreted (Homo sapiens)
DSPGs [extracellular region] (Homo sapiens)
D2,4,4(S)3-PGs [extracellular region] (Homo sapiens)
D2,4,4(S)3-DCN [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07585 DCN
Gene Names
DCN, SLRR1B
Chain
signal peptide:1-16, propeptide:17-30, chain:31-359
Reference Genes
BioGPS Gene:1634 DCN
COSMIC (genes):DCN DCN
CTD Gene:1634 DCN
dbSNP Gene:1634 DCN
ENSEMBL:ENSG00000011465 DCN
HGNC:2705 DCN
KEGG:hsa:1634 DCN
Monarch:1634 DCN
NCBI Gene:1634 DCN
OMIM:125255 DCN
UCSC:P07585 DCN
Reference Transcript
RefSeq:NM_001920.4 DCN
RefSeq:XM_006719270.1 DCN
RefSeq:NM_133505.3 DCN
RefSeq:NM_133506.3 DCN
RefSeq:NM_133504.3 DCN
RefSeq:NM_133503.3 DCN
RefSeq:NM_133507.3 DCN
RefSeq:XM_005268693.1 DCN
RefSeq:XM_017018917.1 DCN
Other Identifiers
11736001_s_at
11736002_s_at
11757283_s_at
11763262_at
1634
201893_PM_x_at
201893_x_at
209335_3p_at
209335_PM_at
209335_at
211813_3p_x_at
211813_PM_x_at
211813_x_at
211896_PM_s_at
211896_s_at
234104_PM_at
234104_at
239786_PM_at
239786_at
240556_PM_at
240556_at
242605_PM_at
242605_at
3465263
3465265
3465267
3465269
3465271
3465273
3465275
3465276
3465277
3465278
3465279
3465280
3465281
3465282
3465283
3465284
3465286
3465287
3465288
3465290
3465292
3465293
3465295
3465297
3465298
3465299
3465300
3465301
3465302
3465303
3465304
3465305
3465306
3465307
3465308
3465309
3465310
3465311
3465312
3465313
3465314
3465331
41947_at
49560_at
66521_at
75521_at
7965410
81256_at
A_23_P64873
A_33_P3382856
GE469763
GE502543
GE61148
GE677201
GE83790
GO:0003723
GO:0005198
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005796
GO:0006355
GO:0009887
GO:0010508
GO:0010596
GO:0016239
GO:0016525
GO:0030021
GO:0030312
GO:0031012
GO:0043202
GO:0045944
GO:0050840
GO:0051897
GO:0051901
GO:0062023
GO:0090141
GO:1900747
HMNXSV003019370
HMNXSV003034310
HMNXSV003054388
Hs.156316.0.A1_3p_at
Hs.27864.0.A1_3p_at
Hs.301495.0.S1_3p_at
Hs.63176.0.A1_3p_at
Hs.76152.0.A2_3p_a_at
Hs.76152.1.A2_3p_at
Hs.76152.1.A2_3p_s_at
ILMN_1683194
ILMN_1768227
ILMN_1838575
ILMN_2347145
PH_hs_0022710
TC12001804.hg
TC12001805.hg
g7381210_3p_s_at
g7381210_3p_x_at
Participates
as a member of
D2,4,4(S)3-PGs [extracellular region] (Homo sapiens)
Other forms of this molecule
XylS-DCN [Golgi lumen]
Gal-Xyl-DCN [Golgi lumen]
DCN [Golgi lumen]
Gal-Gal-Xyl-DCN [Golgi lumen]
GlcA-Gal-Gal-Xyl-DCN [Golgi lumen]
D2,4(S)2-DCN [Golgi lumen]
dermatan-DCN [Golgi lumen]
D4S-DCN [Golgi lumen]
D2,4,4(S)3-DCN [Golgi lumen]
chondroitin(3)-DCN [Golgi lumen]
C4S-DCN [Golgi lumen]
chondroitin(2)-DCN [Golgi lumen]
chondroitin(1)-DCN [Golgi lumen]
D2,4(S)2-DCN [extracellular region]
D4S-DCN [extracellular region]
C6S-DCN [Golgi lumen]
CSE-DCN [Golgi lumen]
C4S-DCN [extracellular region]
C6S-DCN [extracellular region]
CSE-DCN [extracellular region]
C4S-DCN [lysosomal lumen]
C6S-DCN [lysosomal lumen]
CSE-DCN [lysosomal lumen]
DCN [lysosomal lumen]
D4S-DCN [lysosomal lumen]
D2,4(S)2-DCN [lysosomal lumen]
D2,4,4(S)3-DCN [lysosomal lumen]
DCN [extracellular region]
DCN(?-359) [extracellular region]
DCN(31-?) [extracellular region]
Inferred To
Dmel\CG32055 [extracellular region]
(Drosophila melanogaster)
Dcn [extracellular region]
(Mus musculus)
Dcn [extracellular region]
(Rattus norvegicus)
DCN [extracellular region]
(Bos taurus)
DCN [extracellular region]
(Canis familiaris)
DCN [extracellular region]
(Gallus gallus)
DCN [extracellular region]
(Sus scrofa)
dcn [extracellular region]
(Danio rerio)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63519) at unknown position
Modification
beta-D-GalNAc4S-(1->4)-beta-D-IdoA2S-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
OpenTargets
ENSG00000011465
ENSEMBL
ENST00000441303
,
ENST00000547568
,
ENSP00000401021
,
ENST00000552962
,
ENSP00000399815
,
ENSP00000052754
,
ENSP00000447654
,
ENST00000425043
,
ENST00000456569
,
ENST00000052754
,
ENST00000420120
,
ENSP00000447674
,
ENSP00000398514
,
ENSP00000413723
HPA
ENSG00000011465-DCN
PRO
P07585
Pharos - Targets
P07585
Orphanet
DCN
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75063 XYLK
0.623
4
UniProt:P02751 FN1
10
FN1(32-2386) [extracellular region]
(R-HSA-54851)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
0.602
9
UniProt:P13497-2 BMP1
0.558
2
UniProt:Q6TDP4 KLH17
0.527
2
UniProt:Q86X52 CHSY1
5
CHSY1 P539R [Golgi membrane]
(R-HSA-3636862)
CHSY1 E33Sfs*2 [Golgi membrane]
(R-HSA-3636864)
CHSY1 Q69* [Golgi membrane]
(R-HSA-3636838)
CHSY1 G19_L28del [Golgi membrane]
(R-HSA-3636823)
CHSY1 [Golgi membrane]
(R-HSA-1971431)
0.527
2
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