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chondroitin(1)-DCN [Golgi lumen]
Stable Identifier
R-HSA-2064248
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
_DCN, Decorin, PGS2_HUMAN, DCN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective CHSY1 causes TPBS (Homo sapiens)
Defective CHSY1 does not transfer GlcA to chondroitin (Homo sapiens)
chondroitin(1)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(1)-DCN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
Chondroitin sulfate biosynthesis (Homo sapiens)
CHPF,CHPF2,CHSY3 transfer GlcA to chondroitin (Homo sapiens)
chondroitin(1)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(1)-DCN [Golgi lumen] (Homo sapiens)
CHSY1 transfers GlcA to chondroitin (Homo sapiens)
chondroitin(1)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(1)-DCN [Golgi lumen] (Homo sapiens)
The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Homo sapiens)
chondroitin(1)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(1)-DCN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07585 DCN
Gene Names
DCN, SLRR1B
Chain
signal peptide:1-16, propeptide:17-30, chain:31-359
Reference Genes
BioGPS Gene:1634 DCN
COSMIC (genes):DCN DCN
CTD Gene:1634 DCN
dbSNP Gene:1634 DCN
ENSEMBL:ENSG00000011465 DCN
ENSEMBL_homo_sapiens_GENE:ENSG00000011465.18 DCN
HGNC:2705 DCN
KEGG Gene (Homo sapiens):1634 DCN
Monarch:1634 DCN
NCBI Gene:1634 DCN
OMIM:125255 DCN
UCSC:P07585 DCN
Reference Transcript
RefSeq:NM_133504.3 DCN
RefSeq:NM_133506.3 DCN
RefSeq:NM_133503.3 DCN
RefSeq:XM_005268693.1 DCN
RefSeq:XM_017018917.1 DCN
RefSeq:NM_133505.3 DCN
RefSeq:NM_133507.3 DCN
RefSeq:XM_006719270.1 DCN
RefSeq:NM_001920.4 DCN
Other Identifiers
11736001_s_at
11736002_s_at
11757283_s_at
1634
201893_PM_x_at
201893_x_at
209335_3p_at
209335_PM_at
209335_at
211813_3p_x_at
211813_PM_x_at
211813_x_at
211896_PM_s_at
211896_s_at
239786_PM_at
239786_at
3465263
3465265
3465267
3465269
3465271
3465273
3465275
3465276
3465277
3465278
3465279
3465280
3465281
3465282
3465283
3465284
3465288
3465290
3465292
3465293
3465295
3465307
3465308
3465309
3465310
3465314
49560_at
66521_at
7965410
A_23_P64873
A_33_P3382856
GE469763
GE502543
GE61148
GO:0003723
GO:0005198
GO:0005515
GO:0005539
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0006351
GO:0006355
GO:0006914
GO:0007005
GO:0009887
GO:0010508
GO:0010596
GO:0016239
GO:0016525
GO:0023052
GO:0030021
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045944
GO:0048856
GO:0048870
GO:0050840
GO:0051897
GO:0051901
GO:0062023
GO:0090141
GO:1900747
HMNXSV003019370
HMNXSV003054388
Hs.27864.0.A1_3p_at
Hs.76152.0.A2_3p_a_at
Hs.76152.1.A2_3p_at
Hs.76152.1.A2_3p_s_at
ILMN_1683194
ILMN_1768227
ILMN_1838575
ILMN_2347145
PH_hs_0022710
TC12001804.hg
g7381210_3p_s_at
g7381210_3p_x_at
Participates
as a member of
chondroitin(1)-core proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
DCN(31-?) [extracellular region]
DCN(?-359) [extracellular region]
DCN [extracellular region]
dermatan-DCN [Golgi lumen]
D2,4(S)2-DCN [Golgi lumen]
D2,4,4(S)3-DCN [Golgi lumen]
D4S-DCN [Golgi lumen]
CSE-DCN [lysosomal lumen]
C6S-DCN [lysosomal lumen]
C4S-DCN [lysosomal lumen]
D2,4(S)2-DCN [lysosomal lumen]
D4S-DCN [lysosomal lumen]
D4S-DCN [extracellular region]
D2,4(S)2-DCN [extracellular region]
D2,4,4(S)3-DCN [extracellular region]
DCN [lysosomal lumen]
D2,4,4(S)3-DCN [lysosomal lumen]
CSE-DCN [extracellular region]
C6S-DCN [extracellular region]
C4S-DCN [extracellular region]
CSE-DCN [Golgi lumen]
C6S-DCN [Golgi lumen]
C4S-DCN [Golgi lumen]
chondroitin(3)-DCN [Golgi lumen]
chondroitin(2)-DCN [Golgi lumen]
DCN [Golgi lumen]
XylS-DCN [Golgi lumen]
Gal-Xyl-DCN [Golgi lumen]
GlcA-Gal-Gal-Xyl-DCN [Golgi lumen]
Gal-Gal-Xyl-DCN [Golgi lumen]
Inferred To
DCN [Golgi lumen]
(Bos taurus)
DCN [Golgi lumen]
(Canis familiaris)
DCN [Golgi lumen]
(Gallus gallus)
DCN [Golgi lumen]
(Sus scrofa)
Dcn [Golgi lumen]
(Mus musculus)
Dcn [Golgi lumen]
(Rattus norvegicus)
dcn [Golgi lumen]
(Danio rerio)
Dmel\CG32055 [Golgi lumen]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63506) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_598012.1
,
NP_001911.1
,
NP_598010.1
,
XP_005268750.1
,
NP_598011.1
,
NP_598014.1
,
XP_016874406.1
,
NP_598013.1
,
XP_006719333.1
OpenTargets
ENSG00000011465
HPA
ENSG00000011465-DCN
GeneCards
P07585
Ensembl
ENST00000547568
,
ENSP00000447674
,
ENSP00000401021
,
ENSP00000052754
,
ENST00000420120
,
ENSP00000447654
,
ENST00000552962
,
ENSP00000398514
,
ENST00000456569
,
ENSP00000399815
,
ENST00000441303
,
ENSP00000413723
,
ENST00000425043
,
ENST00000052754
,
ENSG00000011465
PRO
P07585
Pharos - Targets
P07585
Orphanet
15853
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75063 XYLK
0.623
4
UniProt:P02751 FN1
10
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713462)
FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane]
(R-HSA-9713459)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.602
9
UniProt:P13497-2 BMP1
0.558
2
UniProt:Q6TDP4 KLH17
0.527
2
UniProt:Q86X52 CHSY1
5
CHSY1 P539R [Golgi membrane]
(R-HSA-3636862)
CHSY1 E33Sfs*2 [Golgi membrane]
(R-HSA-3636864)
CHSY1 Q69* [Golgi membrane]
(R-HSA-3636838)
CHSY1 G19_L28del [Golgi membrane]
(R-HSA-3636823)
CHSY1 [Golgi membrane]
(R-HSA-1971431)
0.527
2
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