Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen]
Stable Identifier
R-HSA-2064141
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
VCAN, Versican core protein, CSPG2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)
GlcA-Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen] (Homo sapiens)
B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)
GlcA-Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen] (Homo sapiens)
Chondroitin sulfate biosynthesis (Homo sapiens)
The addition of GalNAc to the terminal glucuronate residue forms chondroitin (Homo sapiens)
GlcA-Gal-Gal-Xyl-CS proteins [Golgi lumen] (Homo sapiens)
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen] (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
A tetrasaccharide linker sequence is required for GAG synthesis (Homo sapiens)
B3GAT dimers transfer GlcA to tetrasaccharide linker (Homo sapiens)
GlcA-Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen] (Homo sapiens)
B3GAT3 dimer transfers GlcA to tetrasaccharide linker (Homo sapiens)
GlcA-Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13611 VCAN
Gene Names
VCAN, CSPG2
Chain
signal peptide:1-20, chain:21-3396
Reference Genes
BioGPS Gene:1462 VCAN
COSMIC (genes):VCAN VCAN
CTD Gene:1462 VCAN
dbSNP Gene:1462 VCAN
ENSEMBL:ENSG00000038427 VCAN
HGNC:2464 VCAN
KEGG:hsa:1462 VCAN
Monarch:1462 VCAN
NCBI Gene:1462 VCAN
OMIM:118661 VCAN
UCSC:P13611 VCAN
Reference Transcript
RefSeq:NM_001164097.1 VCAN
RefSeq:NM_001126336.2 VCAN
RefSeq:NM_001164098.1 VCAN
RefSeq:NM_004385.4 VCAN
Other Identifiers
11742207_a_at
11742208_a_at
11748164_a_at
11748311_s_at
11755009_s_at
11757783_s_at
11759402_s_at
11759403_x_at
11760056_at
1462
16986913
204619_PM_s_at
204619_s_at
204620_PM_s_at
204620_s_at
211571_PM_s_at
211571_s_at
215646_PM_s_at
215646_s_at
221731_PM_x_at
221731_x_at
2818523
2818524
2818525
2818529
2818530
2818532
2818533
2818534
2818535
2818536
2818543
2818544
2818549
2818550
2818556
2818557
2818558
2818559
2818560
2818561
2818562
2818563
2818564
2818565
2818568
2818571
2818572
2818573
2818577
2818578
2818579
2818580
2818581
2818582
2818583
2818584
2818585
2818586
31682_s_at
38111_at
38112_g_at
45718_at
8106743
A_14_P114502
A_14_P117175
A_14_P117380
A_14_P132108
A_23_P144959
GE61173
GO:0001501
GO:0001649
GO:0001750
GO:0002052
GO:0005198
GO:0005509
GO:0005515
GO:0005539
GO:0005540
GO:0005576
GO:0005615
GO:0005788
GO:0005796
GO:0007155
GO:0007417
GO:0008037
GO:0008160
GO:0008347
GO:0010001
GO:0012505
GO:0016020
GO:0030021
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0033165
GO:0042995
GO:0043202
GO:0045202
GO:0048856
GO:0048870
GO:0062023
GO:0072534
GO:0098772
HMNXSV003046712
Hs.306542.0.S1_3p_at
Hs.81800.0.S2_3p_a_at
Hs.81800.4.A1_3p_a_at
ILMN_1687301
PH_hs_0020300
TC05000412.hg
U16306_at
g1008912_3p_a_at
g1008912_3p_s_at
Participates
as a member of
GlcA-Gal-Gal-Xyl-CS proteins [Golgi lumen] (Homo sapiens)
GlcA-Gal-Gal-Xyl-proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
VCAN [endoplasmic reticulum lumen]
p-VCAN [endoplasmic reticulum lumen]
XylS-VCAN [Golgi lumen]
Gal-Xyl-VCAN [Golgi lumen]
VCAN [Golgi lumen]
Gal-Gal-Xyl-VCAN [Golgi lumen]
D2,4(S)2-VCAN [Golgi lumen]
dermatan-VCAN [Golgi lumen]
D4S-VCAN [Golgi lumen]
D2,4,4(S)3-VCAN [Golgi lumen]
chondroitin(3)-VCAN [Golgi lumen]
C4S-VCAN [Golgi lumen]
chondroitin(2)-VCAN [Golgi lumen]
chondroitin(1)-VCAN [Golgi lumen]
D2,4,4(S)3-VCAN [extracellular region]
D2,4(S)2-VCAN [extracellular region]
D4S-VCAN [extracellular region]
C6S-VCAN [Golgi lumen]
CSE-VCAN [Golgi lumen]
C4S-VCAN [extracellular region]
C6S-VCAN [extracellular region]
CSE-VCAN [extracellular region]
C4S-VCAN [lysosomal lumen]
C6S-VCAN [lysosomal lumen]
CSE-VCAN [lysosomal lumen]
VCAN [lysosomal lumen]
D4S-VCAN [lysosomal lumen]
D2,4(S)2-VCAN [lysosomal lumen]
D2,4,4(S)3-VCAN [lysosomal lumen]
Inferred To
vcanb [Golgi lumen]
(Danio rerio)
vcan [Golgi lumen]
(Xenopus tropicalis)
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen]
(Gallus gallus)
VCAN [Golgi lumen]
(Bos taurus)
VCAN [Golgi lumen]
(Canis familiaris)
VCAN [Golgi lumen]
(Sus scrofa)
Vcan [Golgi lumen]
(Mus musculus)
Vcan [Golgi lumen]
(Rattus norvegicus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63505) at unknown position
Modification
beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001157570.1
,
NP_001157569.1
,
NP_004376.2
,
NP_001119808.1
OpenTargets
ENSG00000038427
ENSEMBL
ENST00000265077
,
ENST00000342785
,
ENSP00000340062
,
ENST00000502527
,
ENST00000343200
,
ENSP00000342768
,
ENSP00000265077
,
ENSP00000421362
HPA
ENSG00000038427-VCAN
PRO
P13611
Pharos - Targets
P13611
GlyGen
P13611
Orphanet
VCAN
HMDB Protein
HMDBP02915
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14780 MMP9
8
MMP9(107-707) [extracellular region]
(R-HSA-668812)
MMP9(20-707) [extracellular region]
(R-HSA-1604376)
MMP9(20-106) [extracellular region]
(R-HSA-1604713)
MMP9(20-59) [extracellular region]
(R-HSA-1604685)
MMP9(60-707) [extracellular region]
(R-HSA-1604726)
MMP9(60-106) [extracellular region]
(R-HSA-1604699)
MMP9 [tertiary granule lumen]
(R-HSA-6800181)
MMP9 [ficolin-1-rich granule lumen]
(R-HSA-6800973)
0.602
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text