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dermatan-VCAN [Golgi lumen]
Stable Identifier
R-HSA-5607517
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
chondroitin(3)-VCAN, _VCAN, Versican core protein, CSPG2_HUMAN, VCAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective CHST14 causes EDS, musculocontractural type (Homo sapiens)
Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)
CHST14 substrates [Golgi lumen] (Homo sapiens)
dermatan-core proteins [Golgi lumen] (Homo sapiens)
dermatan-VCAN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
Dermatan sulfate biosynthesis (Homo sapiens)
CHST14 transfers SO4(2-) to GalNAc in dermatan or DS (Homo sapiens)
CHST14 substrates [Golgi lumen] (Homo sapiens)
dermatan-core proteins [Golgi lumen] (Homo sapiens)
dermatan-VCAN [Golgi lumen] (Homo sapiens)
Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)
DSE,DSEL products [Golgi lumen] (Homo sapiens)
dermatan-core proteins [Golgi lumen] (Homo sapiens)
dermatan-VCAN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13611 VCAN
Gene Names
VCAN, CSPG2
Chain
signal peptide:1-20, chain:21-3396
Reference Genes
BioGPS Gene:1462 VCAN
COSMIC (genes):VCAN VCAN
CTD Gene:1462 VCAN
dbSNP Gene:1462 VCAN
ENSEMBL:ENSG00000038427 VCAN
ENSEMBL_homo_sapiens_GENE:ENSG00000038427.16 VCAN
HGNC:2464 VCAN
KEGG Gene (Homo sapiens):1462 VCAN
Monarch:1462 VCAN
NCBI Gene:1462 VCAN
OMIM:118661 VCAN
UCSC:P13611 VCAN
Reference Transcript
RefSeq:NM_001164097.1 VCAN
RefSeq:NM_004385.4 VCAN
RefSeq:NM_001126336.2 VCAN
RefSeq:NM_001164098.1 VCAN
Other Identifiers
11742207_a_at
11742208_a_at
11748164_a_at
11748311_s_at
11755009_s_at
11757783_s_at
11759402_s_at
11759403_x_at
1462
16986913
204619_PM_s_at
204619_s_at
204620_PM_s_at
204620_s_at
211571_PM_s_at
211571_s_at
215646_PM_s_at
215646_s_at
221731_PM_x_at
221731_x_at
2818523
2818524
2818525
2818529
2818532
2818533
2818534
2818535
2818536
2818543
2818549
2818550
2818559
2818560
2818561
2818562
2818563
2818564
2818565
2818568
2818571
2818572
2818573
2818577
2818578
2818581
2818582
2818583
2818584
2818585
2818586
31682_s_at
38111_at
38112_g_at
45718_at
8106743
A_14_P114502
A_14_P117380
A_14_P132108
A_23_P144959
GE61173
GO:0001501
GO:0001649
GO:0001750
GO:0002052
GO:0005198
GO:0005509
GO:0005515
GO:0005539
GO:0005540
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005929
GO:0007155
GO:0007417
GO:0008037
GO:0008347
GO:0010001
GO:0016020
GO:0030021
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0033165
GO:0042995
GO:0043202
GO:0043226
GO:0045202
GO:0048856
GO:0048870
GO:0062023
GO:0072534
HMNXSV003046712
Hs.81800.0.S2_3p_a_at
Hs.81800.4.A1_3p_a_at
ILMN_1687301
PH_hs_0020300
TC05000412.hg
U16306_at
g1008912_3p_a_at
g1008912_3p_s_at
Participates
as a member of
dermatan-core proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
D2,4(S)2-VCAN [Golgi lumen]
D2,4,4(S)3-VCAN [Golgi lumen]
D4S-VCAN [Golgi lumen]
CSE-VCAN [lysosomal lumen]
C6S-VCAN [lysosomal lumen]
C4S-VCAN [lysosomal lumen]
D2,4(S)2-VCAN [lysosomal lumen]
D4S-VCAN [lysosomal lumen]
D4S-VCAN [extracellular region]
D2,4(S)2-VCAN [extracellular region]
D2,4,4(S)3-VCAN [extracellular region]
VCAN [lysosomal lumen]
D2,4,4(S)3-VCAN [lysosomal lumen]
CSE-VCAN [extracellular region]
C6S-VCAN [extracellular region]
C4S-VCAN [extracellular region]
CSE-VCAN [Golgi lumen]
C6S-VCAN [Golgi lumen]
C4S-VCAN [Golgi lumen]
chondroitin(3)-VCAN [Golgi lumen]
chondroitin(2)-VCAN [Golgi lumen]
chondroitin(1)-VCAN [Golgi lumen]
VCAN [Golgi lumen]
VCAN [endoplasmic reticulum lumen]
p-VCAN [endoplasmic reticulum lumen]
Gal-Gal-Xyl-VCAN [Golgi lumen]
GlcA-Gal-Gal-Xyl-VCAN [Golgi lumen]
Gal-Xyl-VCAN [Golgi lumen]
XylS-VCAN [Golgi lumen]
Inferred To
vcanb [Golgi lumen]
(Danio rerio)
vcan [Golgi lumen]
(Xenopus tropicalis)
VCAN [Golgi lumen]
(Bos taurus)
VCAN [Golgi lumen]
(Canis familiaris)
VCAN [Golgi lumen]
(Sus scrofa)
dermatan-VCAN [Golgi lumen]
(Gallus gallus)
Vcan [Golgi lumen]
(Mus musculus)
Vcan [Golgi lumen]
(Rattus norvegicus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:79163) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-IdoA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001157570.1
,
NP_001119808.1
,
NP_001157569.1
,
NP_004376.2
OpenTargets
ENSG00000038427
HPA
ENSG00000038427-VCAN
GeneCards
P13611
Ensembl
ENSP00000342768
,
ENSP00000421362
,
ENST00000343200
,
ENSP00000265077
,
ENST00000502527
,
ENSP00000340062
,
ENSG00000038427
,
ENST00000342785
,
ENST00000265077
PRO
P13611
Pharos - Targets
P13611
Orphanet
15705
HMDB Protein
HMDBP02915
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14780 MMP9
8
MMP9 [ficolin-1-rich granule lumen]
(R-HSA-6800973)
MMP9 [tertiary granule lumen]
(R-HSA-6800181)
MMP9(60-106) [extracellular region]
(R-HSA-1604699)
MMP9(60-707) [extracellular region]
(R-HSA-1604726)
MMP9(20-59) [extracellular region]
(R-HSA-1604685)
MMP9(20-106) [extracellular region]
(R-HSA-1604713)
MMP9(20-707) [extracellular region]
(R-HSA-1604376)
MMP9(107-707) [extracellular region]
(R-HSA-668812)
0.602
3
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