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chondroitin(3)-BCAN [Golgi lumen]
Stable Identifier
R-HSA-2064138
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
_BCAN, Brevican core protein, PGCB_HUMAN, BCAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective CHST3 causes SEDCJD (Homo sapiens)
Defective CHST3 does not transfer SO4(2-) to chondroitin (Homo sapiens)
chondroitin(3)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(3)-BCAN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
Chondroitin sulfate biosynthesis (Homo sapiens)
CHPF,CHSY3 transfer GalNAc to chondroitin (Homo sapiens)
chondroitin(3)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(3)-BCAN [Golgi lumen] (Homo sapiens)
CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains (Homo sapiens)
chondroitin(3)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(3)-BCAN [Golgi lumen] (Homo sapiens)
CHSY1 transfers GalNAc to chondroitin (Homo sapiens)
chondroitin(3)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(3)-BCAN [Golgi lumen] (Homo sapiens)
Chondroitin can be sulfated on position 4 of GalNAc by CHST9, 11, 12 and 13 (Homo sapiens)
chondroitin(3)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(3)-BCAN [Golgi lumen] (Homo sapiens)
Dermatan sulfate biosynthesis (Homo sapiens)
Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS) (Homo sapiens)
DSE,DSEL substrates [Golgi lumen] (Homo sapiens)
chondroitin(3)-core proteins [Golgi lumen] (Homo sapiens)
chondroitin(3)-BCAN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GW7 BCAN
Gene Names
BCAN, BEHAB, CSPG7, UNQ2525/PRO6018
Chain
signal peptide:1-22, chain:23-911
Reference Genes
BioGPS Gene:63827 BCAN
COSMIC (genes):BCAN BCAN
CTD Gene:63827 BCAN
dbSNP Gene:63827 BCAN
ENSEMBL:ENSG00000132692 BCAN
ENSEMBL_homo_sapiens_GENE:ENSG00000132692.19 BCAN
HGNC:23059 BCAN
KEGG Gene (Homo sapiens):63827 BCAN
Monarch:63827 BCAN
NCBI Gene:63827 BCAN
OMIM:600347 BCAN
UCSC:Q96GW7 BCAN
Reference Transcript
RefSeq:NM_021948.4 BCAN
RefSeq:XM_011509866.1 BCAN
RefSeq:NM_198427.1 BCAN
Other Identifiers
11719950_a_at
11728162_at
16672126
219107_PM_at
219107_at
221623_PM_at
221623_at
2361638
2361639
2361643
2361645
2361646
2361648
2361649
2361650
2361651
2361652
2361653
2361655
2361656
2361657
2361658
2361659
2361660
2361665
2361667
2361669
2361670
2361671
2361672
2361674
2361675
2361676
2361677
4920094C_3p_s_at
60064_g_at
63827
7906205
80560_at
91920_3p_at
91920_PM_at
91920_at
92116_at
A_14_P113766
A_23_P160607
A_24_P358554
GE56735
GO:0001501
GO:0002052
GO:0005515
GO:0005540
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0007155
GO:0007417
GO:0010001
GO:0016020
GO:0021766
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0034330
GO:0043202
GO:0043226
GO:0045202
GO:0048856
GO:0060074
GO:0072534
GO:0098552
GO:0098978
HMNXSV003004458
ILMN_1680300
ILMN_1732154
ILMN_2246131
PH_hs_0022733
TC01001325.hg
g10798902_3p_at
g10798902_3p_x_at
g11345493_3p_at
Participates
as a member of
chondroitin(3)-core proteins [Golgi lumen] (Homo sapiens)
Other forms of this molecule
D2,4,4(S)3-BCAN(361-911) [extracellular region]
CSE-BCAN(361-911) [extracellular region]
C6S-BCAN(361-911) [extracellular region]
C4S-BCAN(361-911) [extracellular region]
D2,4(S)2-BCAN(361-911) [extracellular region]
D4S-BCAN(361-911) [extracellular region]
D4S-BCAN(23-360) [extracellular region]
D2,4(S)2-BCAN(23-360) [extracellular region]
C6S-BCAN(23-360) [extracellular region]
D2,4,4(S)3-BCAN(23-360) [extracellular region]
C4S-BCAN(23-360) [extracellular region]
CSE-BCAN(23-360) [extracellular region]
D2,4(S)2-BCAN(23-395) [extracellular region]
D2,4,4(S)3-BCAN(23-395) [extracellular region]
C6S-BCAN(23-395) [extracellular region]
C4S-BCAN(23-395) [extracellular region]
D4S-BCAN(23-395) [extracellular region]
CSE-BCAN(23-395) [extracellular region]
C4S-BCAN(396-911) [extracellular region]
D2,4,4(S)3-BCAN(396-911) [extracellular region]
C6S-BCAN(396-911) [extracellular region]
D4S-BCAN(396-911) [extracellular region]
CSE-BCAN(396-911) [extracellular region]
D2,4(S)2-BCAN(396-911) [extracellular region]
dermatan-BCAN [Golgi lumen]
D2,4(S)2-BCAN [Golgi lumen]
D2,4,4(S)3-BCAN [Golgi lumen]
D4S-BCAN [Golgi lumen]
CSE-BCAN [lysosomal lumen]
C6S-BCAN [lysosomal lumen]
C4S-BCAN [lysosomal lumen]
D2,4(S)2-BCAN [lysosomal lumen]
D4S-BCAN [lysosomal lumen]
D4S-BCAN [extracellular region]
D2,4(S)2-BCAN [extracellular region]
D2,4,4(S)3-BCAN [extracellular region]
BCAN [lysosomal lumen]
D2,4,4(S)3-BCAN [lysosomal lumen]
CSE-BCAN [extracellular region]
C6S-BCAN [extracellular region]
C4S-BCAN [extracellular region]
CSE-BCAN [Golgi lumen]
C6S-BCAN [Golgi lumen]
Gal-Gal-Xyl-BCAN [Golgi lumen]
GlcA-Gal-Gal-Xyl-BCAN [Golgi lumen]
Gal-Xyl-BCAN [Golgi lumen]
XylS-BCAN [Golgi lumen]
BCAN [Golgi lumen]
chondroitin(1)-BCAN [Golgi lumen]
chondroitin(2)-BCAN [Golgi lumen]
C4S-BCAN [Golgi lumen]
Inferred To
bcan [Golgi lumen]
(Danio rerio)
bcan [Golgi lumen]
(Xenopus tropicalis)
BCAN [Golgi lumen]
(Bos taurus)
BCAN [Golgi lumen]
(Canis familiaris)
BCAN [Golgi lumen]
(Sus scrofa)
Bcan [Golgi lumen]
(Mus musculus)
Bcan [Golgi lumen]
(Rattus norvegicus)
chondroitin(3)-BCAN [Golgi lumen]
(Gallus gallus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63511) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_068767.3
,
NP_940819.1
,
XP_011508168.1
OpenTargets
ENSG00000132692
HPA
ENSG00000132692-BCAN
GeneCards
Q96GW7
Ensembl
ENST00000329117
,
ENSP00000354925
,
ENST00000361588
,
ENSP00000331210
,
ENSG00000132692
PRO
Q96GW7
Pharos - Targets
Q96GW7
HMDB Protein
HMDBP02632
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
LYN [cytosol]
(R-HSA-354251)
0.556
3
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