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AKT phosphorylates targets in the nucleus
Stable Identifier
R-HSA-198693
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
AKT phosphorylates targets in the nucleus (Homo sapiens)
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After translocation into the nucleus, AKT can phosphorylate a number of targets there such as CREB, forkhead transcription factors, SRK and NUR77.
Participants
Events
AKT phosphorylates CREB1
(Homo sapiens)
AKT phosphorylates FOXO transcription factors
(Homo sapiens)
AKT can phosphorylate RSK
(Homo sapiens)
AKT can phosphorylate NR4A1 (NUR77)
(Homo sapiens)
Participates
as an event of
PIP3 activates AKT signaling (Homo sapiens)
Event Information
Go Biological Process
phosphatidylinositol 3-kinase/protein kinase B signal transduction (0043491)
Orthologous Events
AKT phosphorylates targets in the nucleus (Caenorhabditis elegans)
AKT phosphorylates targets in the nucleus (Danio rerio)
AKT phosphorylates targets in the nucleus (Dictyostelium discoideum)
AKT phosphorylates targets in the nucleus (Drosophila melanogaster)
AKT phosphorylates targets in the nucleus (Gallus gallus)
AKT phosphorylates targets in the nucleus (Mus musculus)
AKT phosphorylates targets in the nucleus (Rattus norvegicus)
AKT phosphorylates targets in the nucleus (Saccharomyces cerevisiae)
AKT phosphorylates targets in the nucleus (Schizosaccharomyces pombe)
Cross References
BioModels Database
BIOMD0000000651
,
BIOMD0000000582
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
© 2024
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