Reactome | CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme

CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme

Stable Identifier

R-HSA-198824

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, mitochondrial outer membrane

Synonyms

ferric CYB5A + NADH + H+ => ferrous CYPB5A + NAD+

ReviewStatus

5/5

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CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme

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Cytochrome b5 reductase (CYB5R3) catalyzes the reduction of cytosolic ferric CYB5A (CYB5A:ferriheme) to ferrous CYPB5A (CYB5A:heme), coupled to the conversion of NADH to NAD+ (Shirabe et al. 1995). CYB5R3 is associated with the outer mitochondrial membrane via a myristoyl group added post-translationally to glycine residue 2 of the protein (Borgese et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
8513896	NADH-cytochrome b5 reductase and cytochrome b5 isoforms as models for the study of post-translational targeting to the endoplasmic reticulum De Silvestris, M, Borgese, N, Pietrini, G, D'Arrrigo, A	FEBS Lett	1993
7668255	A novel point mutation in a 3' splice site of the NADH-cytochrome b5 reductase gene results in immunologically undetectable enzyme and impaired NADH-dependent ascorbate regeneration in cultured fibroblasts of a patient with type II hereditary methemoglobinemia Landi, MT, Borgese, N, Fedrizzi, E, Takeshita, M, Shirabe, K, Uziel, G	Am J Hum Genet	1995