CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme

Stable Identifier
R-HSA-198824
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ferric CYB5A + NADH + H+ => ferrous CYPB5A + NAD+
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Cytochrome b5 reductase (CYB5R3) catalyzes the reduction of cytosolic ferric CYB5A (CYB5A:ferriheme) to ferrous CYPB5A (CYB5A:heme), coupled to the conversion of NADH to NAD+ (Shirabe et al. 1995). CYB5R3 is associated with the outer mitochondrial membrane via a myristoyl group added post-translationally to glycine residue 2 of the protein (Borgese et al. 1993).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cytochrome-b5 reductase activity, acting on NAD(P)H of CYB5R3:FAD [mitochondrial outer membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created
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