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ME1 [cytosol]
Stable Identifier
R-HSA-400119
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NADP-dependent malic enzyme, MAOX_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
NFE2L2 regulating TCA cycle genes (Homo sapiens)
NFE2L2-dependent ME1 gene expression (Homo sapiens)
ME1 tetramer [cytosol] (Homo sapiens)
ME1 dimer [cytosol] (Homo sapiens)
ME1:Mg2+/Mn2+ [cytosol] (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
ME1 tetramer decarboxylates MAL to PYR (Homo sapiens)
ME1 tetramer [cytosol] (Homo sapiens)
ME1 dimer [cytosol] (Homo sapiens)
ME1:Mg2+/Mn2+ [cytosol] (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
ME1 tetramer decarboxylates OA to PYR (Homo sapiens)
ME1 tetramer [cytosol] (Homo sapiens)
ME1 dimer [cytosol] (Homo sapiens)
ME1:Mg2+/Mn2+ [cytosol] (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
ME1 tetramerizes (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
ME1 tetramer [cytosol] (Homo sapiens)
ME1 dimer [cytosol] (Homo sapiens)
ME1:Mg2+/Mn2+ [cytosol] (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
NEK1 phosphorylates ME1 (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ME1 (Homo sapiens)
ME1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48163 ME1
Gene Names
ME1
Chain
chain:1-572
Reference Genes
BioGPS Gene:4199 ME1
COSMIC (genes):ME1 ME1
CTD Gene:4199 ME1
dbSNP Gene:4199 ME1
ENSEMBL:ENSG00000065833 ME1
HGNC:6983 ME1
KEGG:hsa:4199 ME1
Monarch:4199 ME1
NCBI Gene:4199 ME1
OMIM:154250 ME1
UCSC:P48163 ME1
Reference Transcript
RefSeq:NM_002395.5 ME1
RefSeq:XM_011535836.2 ME1
Other Identifiers
11726265_at
11750913_a_at
17021217
204058_PM_at
204058_at
204059_PM_s_at
204059_s_at
2962821
2962822
2962823
2962824
2962825
2962826
2962827
2962828
2962829
2962831
2962837
2962847
2962849
2962850
2962858
2962859
2962868
2962869
31824_at
4199
8127854
837_s_at
A_23_P422026
A_23_P8196
GE57728
GO:0000287
GO:0003824
GO:0004470
GO:0004473
GO:0005515
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006090
GO:0006108
GO:0006734
GO:0006739
GO:0008948
GO:0009055
GO:0009165
GO:0009725
GO:0009743
GO:0016491
GO:0016616
GO:0016829
GO:0030145
GO:0042802
GO:0043226
GO:0043531
GO:0046872
GO:0050661
GO:0051287
GO:0051289
GO:0055086
GO:0065003
GO:1902031
HMNXSV003041291
Hs.14732.0.S2_3p_at
ILMN_1736042
PH_hs_0001390
TC06001912.hg
U43944_at
g13435400_3p_a_at
Participates
as an input of
NEK1 phosphorylates ME1 (Homo sapiens)
ME1 tetramerizes (Homo sapiens)
as an output of
PGAM5 dodecamer dephosphorylates p-S336-ME1 (Homo sapiens)
Expression of ME1 (Homo sapiens)
as a component of
ME1:Mg2+/Mn2+ [cytosol] (Homo sapiens)
Other forms of this molecule
p-S336-ME1 [cytosol]
Inferred To
ME1 [cytosol]
(Bos taurus)
ME1 [cytosol]
(Caenorhabditis elegans)
ME1 [cytosol]
(Canis familiaris)
ME1 [cytosol]
(Danio rerio)
ME1 [cytosol]
(Drosophila melanogaster)
ME1 [cytosol]
(Gallus gallus)
ME1 [cytosol]
(Mus musculus)
ME1 [cytosol]
(Rattus norvegicus)
ME1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_011534138.1
,
NP_002386.1
ENSEMBL
ENSP00000358719
,
ENST00000369705
OpenTargets
ENSG00000065833
HPA
ENSG00000065833-ME1
ZINC - Substances
MAOX_HUMAN
ZINC target
P48163
PRO
P48163
Pharos - Targets
P48163
GlyGen
P48163
ZINC - Predictions - Purchasable
MAOX_HUMAN
HMDB Protein
HMDBP00857
PDB
7X12
,
7X11
,
3WJA
,
2AW5
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P48163 ME1
2
p-S336-ME1 [cytosol]
(R-HSA-9861606)
ME1 [cytosol]
(R-HSA-400119)
0.683
5
UniProt:P11498 PC
3
Btn-PC [mitochondrial matrix]
(R-HSA-2993804)
PC [cytosol]
(R-HSA-3323119)
Btn-PC [cytosol]
(R-HSA-3323170)
0.668
14
UniProt:P40925 MDH1
1
MDH1 [cytosol]
(R-HSA-198471)
0.62
11
UniProt:Q9Y324 FCF1
1
FCF1 [nucleoplasm]
(R-HSA-6790672)
0.527
2
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