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IL6R [plasma membrane]
Stable Identifier
R-HSA-197824
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
IL6RA, Interleukin-6 receptor alpha chain, IL6RA_HUMAN, CD126
Locations in the PathwayBrowser for interactor UniProt:Q9HCU0 CD248
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Activation of STAT3 by cadherin engagement (Homo sapiens)
IL6 binds IL6R (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Developmental Biology (Homo sapiens)
Transcriptional regulation of granulopoiesis (Homo sapiens)
IL6R gene expression is enhanced by CEBPA (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
IL6R binds IL6R inhibitors (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-6 family signaling (Homo sapiens)
Interleukin-6 signaling (Homo sapiens)
IL6 binds IL6R (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
IL6R binds IL6R inhibitors (Homo sapiens)
IL6R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08887 IL6R
Gene Names
IL6R
Chain
signal peptide:1-19, chain:20-468, chain:20-355
Reference Genes
BioGPS Gene:3570 IL6R
COSMIC - genes:IL6R IL6R
CTD Gene:3570 IL6R
dbSNP Gene:3570 IL6R
ENSEMBL:ENSG00000160712 IL6R
HGNC:6019 IL6R
KEGG:hsa:3570 IL6R
Monarch:3570 IL6R
NCBI Gene:3570 IL6R
OMIM:147880 IL6R
UCSC:P08887 IL6R
Reference Transcript
RefSeq:NM_000565.4 IL6R
RefSeq:NM_181359.3 IL6R
RefSeq:NM_001206866.1 IL6R
Participates
as a member of
STAT3-upregulated plasma membrane proteins [plasma membrane] (Homo sapiens)
as an output of
IL6R gene expression is enhanced by CEBPA (Homo sapiens)
as an input of
IL6R binds IL6R inhibitors (Homo sapiens)
IL6 binds IL6R (Homo sapiens)
as a component of
IL6R:IL6R inhibitors [plasma membrane] (Homo sapiens)
IL6:IL6R [plasma membrane] (Homo sapiens)
Inferred To
cntfr [plasma membrane]
(Danio rerio)
IL6R [plasma membrane]
(Bos taurus)
IL6R [plasma membrane]
(Canis familiaris)
IL6R [plasma membrane]
(Gallus gallus)
IL6R [plasma membrane]
(Sus scrofa)
il11ra [plasma membrane]
(Danio rerio)
il11ra [plasma membrane]
(Xenopus tropicalis)
Il6ra [plasma membrane]
(Mus musculus)
Homologues of IL6R [plasma membrane]
(Danio rerio)
Il6r [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000556.1
,
NP_852004.1
,
NP_001193795.1
Guide to Pharmacology - Targets
1708
OpenTargets
ENSG00000160712
ENSEMBL
ENSP00000357470
,
ENSP00000340589
,
ENSG00000160712
,
ENST00000368485
,
ENST00000344086
HPA
ENSG00000160712-IL6R
GeneCards
IL6R
PRO
P08887
Pharos - Targets
P08887
Orphanet
IL6R
GlyGen
P08887
PDB
8QY6
,
8J6F
,
8IOW
,
8QY5
,
8D82
,
1P9M
,
7DC8
,
1N26
,
5FUC
,
2ARW
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05231 IL6
3
IL6 [extracellular region]
(R-HSA-447100)
IL6 [endoplasmic reticulum lumen]
(R-HSA-8956764)
p-IL6 [endoplasmic reticulum lumen]
(R-HSA-8957044)
0.909
11
UniProt:Q92673 SORL1
2
SORL1 [endosome membrane]
(R-HSA-8871475)
SORL1 [Golgi membrane]
(R-HSA-8871510)
0.619
7
UniProt:Q2HRC7 VIL6
0.591
3
UniProt:Q9HCU0 CD248
0.558
2
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:Q6UXK2 ISLR2
0.544
2
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