IL6R gene expression is enhanced by CEBPA

Stable Identifier
R-HSA-9634430
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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IL6R gene expression is enhanced by CEBPA
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CEBPA activates transcription of the IL6R gene, which encodes the receptor for IL6 (interleukin-6, IL-6) (inferred from mouse homologs). Based on inferences from gene knockouts in mice, CEBPA activates both IL6R and CSF3R and is required for granulopoiesis. In mice, the defect in granulopoiesis caused by loss of Cebpa can be rescued by addition of soluble Il6ra plus Il6 or by addition of Csf3r.
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
CEBPA [nucleoplasm] (Homo sapiens)
Inferred From
Il6ra gene expression is enhanced by Cebpa (Mus musculus)
Authored
May, B  (2018-09-22)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2019-01-11)
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