IL6R gene expression is enhanced by CEBPA

Stable Identifier
R-HSA-9634430
Type
Reaction [omitted]
Species
Homo sapiens
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CEBPA activates transcription of the IL6R gene, which encodes the receptor for IL6 (interleukin-6, IL-6) (inferred from mouse homologs). Based on inferences from gene knockouts in mice, CEBPA activates both IL6R and CSF3R and is required for granulopoiesis. In mice, the defect in granulopoiesis caused by loss of Cebpa can be rescued by addition of soluble Il6ra plus Il6 or by addition of Csf3r.

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