Reactome | FCER1A [plasma membrane]

FCER1A [plasma membrane]

Stable Identifier

R-HSA-197802

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

FCERIA, High affinity immunoglobulin epsilon receptor alpha-subunit precursor, FCEA_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - Allergen dependent IgE bound FCERI aggregation (Homo sapiens)
      - FCERI:IgE [plasma membrane] (Homo sapiens)
        
        FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE [plasma membrane] (Homo sapiens)
        
        FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - FCERI mediated Ca+2 mobilization (Homo sapiens)
      - Phosphorylation of PLC-gamma (Homo sapiens)
        
        p-SYK/p-BTK [plasma membrane] (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - FCERI mediated MAPK activation (Homo sapiens)
      - Phosphorylation of SHC by SYK kinase (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - FCERI mediated NF-kB activation (Homo sapiens)
      - Phosphorylation of PKC-theta (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - IgE binds FCERI (Homo sapiens)
      - FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - FCERI:IgE [plasma membrane] (Homo sapiens)
        
        FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - Phosphorylation of LAT by p-SYK (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - Phosphorylation of SYK (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - Phosphorylation of beta and gamma subunits by LYN (Homo sapiens)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        FCERI:IgE [plasma membrane] (Homo sapiens)
        
        FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Homo sapiens)
      - Phosphorylation of GAB2 by SYK/FYN (Homo sapiens)
        
        SYK/FYN [plasma membrane] (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)
      - Phosphorylation of NTAL by p-SYK/Lyn (Homo sapiens)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Homo sapiens)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI aggregate [plasma membrane] (Homo sapiens)
        
        p-FCERI [plasma membrane] (Homo sapiens)
        
        FCER1A [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12319 FCER1A

Gene Names

FCER1A, FCE1A

Chain

signal peptide:1-25, chain:26-257

Reference Genes

BioGPS Gene:2205 FCER1A

COSMIC (genes):FCER1A FCER1A

CTD Gene:2205 FCER1A

dbSNP Gene:2205 FCER1A

ENSEMBL:ENSG00000179639 FCER1A

ENSEMBL_homo_sapiens_GENE:ENSG00000179639.11 FCER1A

ENSEMBL_homo_sapiens_GENE:ENSG00000291905.1 FCER1A

HGNC:3609 FCER1A

KEGG Gene (Homo sapiens):2205 FCER1A

Monarch:2205 FCER1A

NCBI Gene:2205 FCER1A

OMIM:147140 FCER1A

UCSC:P12319 FCER1A

Reference Transcript

RefSeq:NM_002001.3 FCER1A

Other Identifiers

11728532_at

16672435

211734_PM_s_at

211734_s_at

2205

2362538

2362541

2362542

2362545

2362546

2362548

2362549

2362550

34023_at

7906443

A_23_P103765

GE59685

GO:0002376

GO:0004888

GO:0005515

GO:0005886

GO:0006954

GO:0007166

GO:0009986

GO:0016020

GO:0016068

GO:0016192

GO:0019768

GO:0019863

GO:0023052

GO:0038095

GO:0042092

GO:0043303

GO:0043308

GO:0050776

GO:0060089

HMNXSV003024959

ILMN_1688423

PH_hs_0000108

PH_hs_0030858

TC01001351.hg

X06948_at

g13543505_3p_s_at

Participates

as a component of

Inferred To

Fcer1a [plasma membrane] (Mus musculus)

Fcer1a [plasma membrane] (Rattus norvegicus)

FCER1A [plasma membrane] (Bos taurus)

FCER1A [plasma membrane] (Canis familiaris)

FCER1A [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_001992.1

Guide to Pharmacology - Targets

2933

OpenTargets

ENSG00000179639

HPA

ENSG00000179639-FCER1A

GeneCards

P12319

ZINC target

P12319

Ensembl

ENSG00000179639, ENST00000693622, ENSP00000509626, ENST00000368115, ENSP00000357097

PRO

P12319

Pharos - Targets

P12319

PDB

1J88, 8C1C, 8C1B, 1F6A, 2Y7Q, 1J89, 1F2Q, 7SHT, 1J86, 1RPQ, 1J87

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