Reactome | FCER1A [plasma membrane]

FCER1A [plasma membrane]

Stable Identifier

R-BTA-197802

Type

Protein [EntityWithAccessionedSequence]

Species

Bos taurus

Compartment

plasma membrane

Synonyms

FCER1A, A6QQQ4

Locations in the PathwayBrowser

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Immune System (Bos taurus)

- Innate Immune System (Bos taurus)
  - Fc epsilon receptor (FCERI) signaling (Bos taurus)
    - Allergen dependent IgE bound FCERI aggregation (Bos taurus)
      - FCERI:IgE [plasma membrane] (Bos taurus)
        
        FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE [plasma membrane] (Bos taurus)
        
        FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - FCERI mediated Ca+2 mobilization (Bos taurus)
      - Phosphorylation of TEC kinases by p-SYK (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - FCERI mediated MAPK activation (Bos taurus)
      - Phosphorylation of SHC by SYK kinase (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
      - Phosphorylation of SLP-76 by p-SYK (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - FCERI mediated NF-kB activation (Bos taurus)
      - Phosphorylation of PKC-theta (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - IgE binds FCERI (Bos taurus)
      - FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
      - FCERI:IgE [plasma membrane] (Bos taurus)
        
        FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - Phosphorylation of LAT by p-SYK (Bos taurus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - Phosphorylation of beta and gamma subunits by LYN (Bos taurus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
      - FCERI:IgE:Allergen aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        FCERI:IgE [plasma membrane] (Bos taurus)
        
        FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - Recruitment of SYK to p-FCERI gamma subunit (Bos taurus)
      - Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
      - Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)
    - Role of LAT2/NTAL/LAB on calcium mobilization (Bos taurus)
      - Phosphorylation of NTAL by p-SYK/Lyn (Bos taurus)
        
        Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Bos taurus)
        
        Allergen:p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-LYN:p-FCERI:IgE aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI aggregate [plasma membrane] (Bos taurus)
        
        p-FCERI [plasma membrane] (Bos taurus)
        
        FCER1A [plasma membrane] (Bos taurus)

External Reference Information

External Reference

UniProt:A6QQQ4

Gene Names

FCER1A

Reference Genes

BioGPS Gene:506783 FCER1A

ENSEMBL:ENSBTAG00000012887.5

KEGG Gene (Bos taurus):506783 FCER1A

Monarch:506783 FCER1A

NCBI Gene:506783 FCER1A

Reference Transcript

RefSeq:NM_001100310.2 FCER1A

Other Identifiers

506783

GO:0002376

GO:0004888

GO:0005886

GO:0006954

GO:0007166

GO:0009986

GO:0016020

GO:0016068

GO:0016192

GO:0019768

GO:0019863

GO:0023052

GO:0038095

GO:0042092

GO:0043303

GO:0043308

GO:0050776

GO:0060089

Participates

as a component of

Inferred From

FCER1A [plasma membrane] (Homo sapiens)

Cross References

RefSeq

NP_001093780.1

OpenTargets

ENSG00000179639

Ensembl

ENSBTAT00000017127, ENSBTAP00000017127, ENSBTAG00000012887

VGNC

28930

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